Preparation and characterization of alginate/silver/nicotinamide nanocomposites for treating diabetic wounds
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27431797
DOI
10.1016/j.ijbiomac.2016.07.050
PII: S0141-8130(16)30873-X
Knihovny.cz E-zdroje
- Klíčová slova
- Nanocomposite, Nonwoven fabrics, Wound dressing,
- MeSH
- algináty chemie MeSH
- antiflogistika nesteroidní farmakologie MeSH
- aplikace kožní MeSH
- Escherichia coli účinky léků růst a vývoj MeSH
- experimentální diabetes mellitus chemicky indukované komplikace farmakoterapie mikrobiologie MeSH
- infekce vyvolané Escherichia coli komplikace farmakoterapie mikrobiologie patologie MeSH
- kovové nanočástice chemie ultrastruktura MeSH
- králíci MeSH
- krysa rodu Rattus MeSH
- kůže účinky léků mikrobiologie patologie MeSH
- kyselina glukuronová chemie MeSH
- kyseliny hexuronové chemie MeSH
- nanokompozity chemie ultrastruktura MeSH
- niacinamid farmakologie MeSH
- obvazy * MeSH
- popálení farmakoterapie mikrobiologie patologie MeSH
- stafylokokové infekce komplikace farmakoterapie mikrobiologie patologie MeSH
- Staphylococcus aureus účinky léků růst a vývoj MeSH
- streptozocin MeSH
- stříbro chemie MeSH
- textilie MeSH
- velikost částic MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- algináty MeSH
- antiflogistika nesteroidní MeSH
- kyselina glukuronová MeSH
- kyseliny hexuronové MeSH
- niacinamid MeSH
- streptozocin MeSH
- stříbro MeSH
Silver/Alginate/Nicotinamide nanoparticles composite (Ag/ALG/Nic) was prepared and used for the first time to fabricate wound dressing material. Sodium alginate (ALG) was used as reducing and stabilizing agents for preparation of silver nanoparticles (Ag-NPs). Effect of concentrations of alginate (ALG) on the particle size of silver were studied and confirmed by different techniques like UV/vis spectroscopy, transmission electron microscope (TEM) and dynamic light scattering (DLS). Nonwoven viscous fabrics were used as a carrier for silver/alginate/nanoparticles composite by impregnated the nonwoven fabrics as per the padding-curing technique. Nicotinamide (Nic) as anti-inflammatory drug was entrapped into Ag-NPS/ALG/nonwoven fabrics. Scanning electron microscope and energy dispersive x-ray (SEM-EDX) were used to evaluate the presence of Ag/ALG/Nic nanoparticles composite anchored the nonwoven fabrics. The antibacterial activity of the Ag/ALG/Nic wound dressing material was evaluated against Escherichia coli (E. coli) and Staphylococcus Aureus (St. Aureus). The wound healing and histological studied were evaluated by using burn diabetic rat animals.
National Research Centre Pathology Department Dokki Cairo Egypt
National Research Centre Pharmacology Department Dokki Cairo Egypt
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