The aging effect on prostate metabolite concentrations measured by 1H MR spectroscopy
Language English Country Germany Media print-electronic
Document type Journal Article
PubMed
27522359
DOI
10.1007/s10334-016-0584-x
PII: 10.1007/s10334-016-0584-x
Knihovny.cz E-resources
- Keywords
- 1H MRS, Aging, Choline, Citrate, Creatine, Polyamines, Prostate, Spermine,
- MeSH
- Choline chemistry MeSH
- Citrates chemistry MeSH
- Adult MeSH
- Creatinine chemistry MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy * MeSH
- Magnetic Fields MeSH
- Young Adult MeSH
- Prostatic Neoplasms diagnostic imaging metabolism pathology MeSH
- Polyamines chemistry MeSH
- Prostate diagnostic imaging metabolism MeSH
- Decision Making MeSH
- Aged MeSH
- Spermine analysis MeSH
- Zinc analysis MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Choline MeSH
- Citrates MeSH
- Creatinine MeSH
- Polyamines MeSH
- Spermine MeSH
- Zinc MeSH
OBJECTIVE: The effects of aging, magnetic field and the voxel localization on measured concentrations of citrate (Cit), creatine (Cr), cholines (Cho) and polyamines (PA) in a healthy prostate were evaluated. MATERIALS AND METHODS: 36 examinations at both 1.5T and 3T imagers of 52 healthy subjects aged 19-71 years were performed with PRESS 3D-CSI sequences (TE = 120 and 145 ms). Concentrations in laboratory units and their ratios to citrate were calculated using the LCModel technique. Absolute concentrations were also obtained after the application of correction coefficients. Statistical analysis was performed using a robust linear mixed effects model. RESULTS: Significant effects of aging, the magnetic field strength and the voxel position in central (CZ) or peripheral (PZ) zones on all measured metabolites were found. The concentrations (mmol/kg wet tissue) including prediction intervals in a range of 20-70 years were found: Cit: 7.9-17.2; Cho: 1.4-1.7; Cr: 2.8-2.5; PA (as spermine): 0.6-2.1 at 3T in CZ. In PZ, the concentrations were higher by about 10 % as compared to CZ. CONCLUSION: Increasing citrate and spermine concentrations with age are significant and correlate well with a recently described increase of zinc in the prostate. These findings should be considered in decision-making if the values obtained from a subject are in the range of control values.
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