The aging effect on prostate metabolite concentrations measured by 1H MR spectroscopy
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27522359
DOI
10.1007/s10334-016-0584-x
PII: 10.1007/s10334-016-0584-x
Knihovny.cz E-zdroje
- Klíčová slova
- 1H MRS, Aging, Choline, Citrate, Creatine, Polyamines, Prostate, Spermine,
- MeSH
- cholin chemie MeSH
- citráty chemie MeSH
- dospělí MeSH
- kreatinin chemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie * MeSH
- magnetické pole MeSH
- mladý dospělý MeSH
- nádory prostaty diagnostické zobrazování metabolismus patologie MeSH
- polyaminy chemie MeSH
- prostata diagnostické zobrazování metabolismus MeSH
- rozhodování MeSH
- senioři MeSH
- spermin analýza MeSH
- zinek analýza MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cholin MeSH
- citráty MeSH
- kreatinin MeSH
- polyaminy MeSH
- spermin MeSH
- zinek MeSH
OBJECTIVE: The effects of aging, magnetic field and the voxel localization on measured concentrations of citrate (Cit), creatine (Cr), cholines (Cho) and polyamines (PA) in a healthy prostate were evaluated. MATERIALS AND METHODS: 36 examinations at both 1.5T and 3T imagers of 52 healthy subjects aged 19-71 years were performed with PRESS 3D-CSI sequences (TE = 120 and 145 ms). Concentrations in laboratory units and their ratios to citrate were calculated using the LCModel technique. Absolute concentrations were also obtained after the application of correction coefficients. Statistical analysis was performed using a robust linear mixed effects model. RESULTS: Significant effects of aging, the magnetic field strength and the voxel position in central (CZ) or peripheral (PZ) zones on all measured metabolites were found. The concentrations (mmol/kg wet tissue) including prediction intervals in a range of 20-70 years were found: Cit: 7.9-17.2; Cho: 1.4-1.7; Cr: 2.8-2.5; PA (as spermine): 0.6-2.1 at 3T in CZ. In PZ, the concentrations were higher by about 10 % as compared to CZ. CONCLUSION: Increasing citrate and spermine concentrations with age are significant and correlate well with a recently described increase of zinc in the prostate. These findings should be considered in decision-making if the values obtained from a subject are in the range of control values.
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