AIMS: Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. METHODS AND RESULTS: A total of 10 registries (documenting 84 054 NSTE-ACS patients) provided data in a systematic manner on patient characteristics and outcomes for NSTE-ACS in general, and 6 of these (with 52 173 NSTE-ACS patients) also provided more specific data according to P2Y12 receptor inhibitor used. Unadjusted analyses were performed at the study level, and no formal meta-analysis was performed due to large heterogeneity between studies in the settings, patient characteristics, and outcome definitions. All-cause death rates across registries ranged from 0.76 to 4.79% in-hospital, from 1.61 to 6.65% at 30 days, from 3.66 to 7.16% at 180 days, and from 3.14 to 9.73% at 1 year. Major bleeding events were reported in up to 2.77% of patients while in hospital (in seven registries), up to 1.08% at 30 days (data from one registry only), and 2.06% at 1 year (one registry). CONCLUSIONS: There were substantial differences in the use of and patient selection for clopidogrel, prasugrel, and ticagrelor, which were associated with differences in short- and long-term ischaemic and bleeding events. In future registries, data collection should be performed in a more standardized way with respect to endpoints, definitions, and time points.

2nd Department of Medicine with Cardiology and Intensive Care Hospital Rudolfstiftung Vienna Austria

AMIS Plus Data Center Epidemiology Biostatistics and Prevention Institute University of Zurich Zurich Switzerland

AMIS Plus Data Center University of Zurich Zurich Switzerland

Cardiac Intensive Care Unit Interventional Cardiology Hopital Cardiologique Centre Hospitalier Régional et Universitaire de Lille Lille France

Cardiocenter 3rd Faculty of Medicine Charles University Prague Czech Republic

Cardiology Department Hospital La Paz IdiPaz Madrid Spain

Cardiology Department University Heart Center University Hospital Zurich University of Zurich Zurich Switzerland

Cardiology Freeman Hospital and Institute of Cellular Medicine Newcastle upon Tyne UK

Cardiology Service Hospital Universitari de Tarragona Joan XXIII IISPV Tarragona Spain

Cardiology Service Hospital Universitari Vall d'Hebron Barcelona Spain

Cardiology Unit Humanitas Research Hospital Rozzano Milano Italy

Department of Cardiology Hospital Européen Georges Pompidou and Université Paris Descartes Paris France

Department of Cardiology Leiden University Medical Center Leiden The Netherlands

Department of Cardiology Lund University Skåne University Hospital Lund Lund Sweden

Department of Cardiology University Hospital Antwerp Edegem Belgium

Department of Cardiovascular Sciences Laboratory of Interventional Cardiology European Hospital Rome Italy

Heart Disease Institute Bellvitge University Hospital IDIBELL University of Barcelona Barcelona Spain

Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen Bremser Str 79 D 67063 Ludwigshafen Germany

Pôle de l'urgence Service de SAMU du Nord Centre Hospitalier régional Universitaire de Lille Lille France

Swansea University Medical School Swansea Wales UK

Université Paris 06 ACTION Study Group INSERM UMRS 1166 Institut de Cardiologie Pitié Salpêtrière University Hospital Paris France

University Clinic of Internal Medicine 3 Cardiology and Angiology Medical University of Innsbruck Innsbruck Austria

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