Radiotherapy management of brain metastases using conventional linear accelerator
Language English Country Czech Republic Media print-electronic
Document type Evaluation Study, Journal Article
PubMed
27641139
DOI
10.5507/bp.2016.043
Knihovny.cz E-resources
- Keywords
- brain, metastases, radiosurgery, radiotherapy, stereotactic, treatment,
- MeSH
- Particle Accelerators MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Brain Neoplasms mortality radiotherapy secondary MeSH
- Radiosurgery instrumentation mortality MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Feasibility Studies MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
BACKGROUND AND AIMS: As treatments for primary cancers continue to improve life expectancy, unfortunately, brain metastases also appear to be constantly increasing and life expectancy for patients with brain metastases is low. Longer survival and improved quality of life may be achieved using localised radiological and surgical approaches in addition to low dose corticosteroids. Stereotactic brain radiotherapy is one rapidly evolving localized radiation treatment. This article describes our experience with stereotactic radiotherapy using a linear accelerator. METHODS: We reviewed patients treated with stereotactic radiotherapy, from the time of its introduction into daily practice in our Department of Oncology in 2014. We collected the data on patient treatment and predicted survival based on prognostic indices and actual patient outcome. RESULTS: A total of 10 patients were treated by stereotactic radiotherapy, in one case in combination with whole brain radiotherapy and hippocampal sparing. There was no significant treatment related toxicity during the treatment or follow-up and due to the small number of fractions, the overall tolerance of the treatment was excellent. The patient intrafractional movement in all cases was under 1 mm suggesting that 1 mm margin around the CTV to create the PTV is sufficient and also that patient immobilization using the thermoplastic mask compared with invasive techniques, is feasible. We also found that prognostic indices such as the Graded Prognostic Assessment provide accurate predictions of patient survival. CONCLUSIONS: Based on our current evidence, patients with brain metastases fit enough, should be considered for stereotactic radiotherapy treatment.
Department of Oncology Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic
Toxicogenomics Unit National Institute of Public Health Prague Czech Republic
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