Mechanisms of hormonal regulation of the peripheral circadian clock in the colon
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Circadian clock, colon, entrainment,
- MeSH
- Circadian Clocks physiology MeSH
- Period Circadian Proteins genetics metabolism MeSH
- Pineal Gland surgery MeSH
- Photoperiod * MeSH
- Mice, Inbred Strains MeSH
- Colon physiology MeSH
- Rats MeSH
- Mutation MeSH
- Mice MeSH
- Adrenal Glands surgery MeSH
- Rats, Wistar MeSH
- Gene Expression Regulation physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Period Circadian Proteins MeSH
- Per2 protein, mouse MeSH Browser
Colonic function is controlled by an endogenous clock that allows the colon to optimize its function on the daytime basis. For the first time, this study provided evidence that the clock is synchronized by rhythmic hormonal signals. In rat colon, adrenalectomy decreased and repeated applications of dexamethasone selectively rescued circadian rhythm in the expression of the clock gene Per1. Dexamethasone entrained the colonic clock in explants from mPer2Luc mice in vitro. In contrast, pinealectomy had no effect on the rat colonic clock, and repeated melatonin injections were not able to rescue the clock in animals maintained in constant light. Additionally, melatonin did not entrain the clock in colonic explants from mPer2Luc mice in vitro. However, melatonin affected rhythmic regulation of Nr1d1 gene expression in vivo. The findings provide novel insight into possible beneficial effects of glucocorticoids in the treatment of digestive tract-related diseases, greatly exceeding their anti-inflammatory action.
References provided by Crossref.org
Alteration in glucose homeostasis and persistence of the pancreatic clock in aged mPer2Luc mice
