Mechanisms of hormonal regulation of the peripheral circadian clock in the colon
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- Klíčová slova
- Circadian clock, colon, entrainment,
- MeSH
- cirkadiánní hodiny fyziologie MeSH
- cirkadiánní proteiny Period genetika metabolismus MeSH
- epifýza mozková chirurgie MeSH
- fotoperioda * MeSH
- inbrední kmeny myší MeSH
- kolon fyziologie MeSH
- krysa rodu Rattus MeSH
- mutace MeSH
- myši MeSH
- nadledviny chirurgie MeSH
- potkani Wistar MeSH
- regulace genové exprese fyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cirkadiánní proteiny Period MeSH
- Per2 protein, mouse MeSH Prohlížeč
Colonic function is controlled by an endogenous clock that allows the colon to optimize its function on the daytime basis. For the first time, this study provided evidence that the clock is synchronized by rhythmic hormonal signals. In rat colon, adrenalectomy decreased and repeated applications of dexamethasone selectively rescued circadian rhythm in the expression of the clock gene Per1. Dexamethasone entrained the colonic clock in explants from mPer2Luc mice in vitro. In contrast, pinealectomy had no effect on the rat colonic clock, and repeated melatonin injections were not able to rescue the clock in animals maintained in constant light. Additionally, melatonin did not entrain the clock in colonic explants from mPer2Luc mice in vitro. However, melatonin affected rhythmic regulation of Nr1d1 gene expression in vivo. The findings provide novel insight into possible beneficial effects of glucocorticoids in the treatment of digestive tract-related diseases, greatly exceeding their anti-inflammatory action.
Citace poskytuje Crossref.org
Alteration in glucose homeostasis and persistence of the pancreatic clock in aged mPer2Luc mice
