A significant part of current research studies utilizes various cellular models which imply specific antibiotics-containing media as well as antibiotics used for clonal selection or promoter de/activation. With the great success of developing such tools, mitochondria, once originated from bacteria, can be effectively targeted by antibiotics. For that reason, some studies propose antibiotics-targeting of mitochondria as part of anticancer therapy. Here, we have focused on the effects of various classes of antibiotics on mitochondria in cancer and non-cancer cells and demonlow mitochondrial membrane potential, reduced ATP production, altered morphology and lowered respiration rate which altogether suggested mitochondrial dysfunction (MDF). This was in parallel with increased level of reactive oxygen species (ROS) and decreased activity of mitochondrial respiration complexes. However, both survival and repopulation capacity of cancer cells was not significantly affected by the antibiotics, perhaps due to a glycolytic shift or activated autophagy. In turn, simultaneous inhibition of autophagy and treatment with antibiotics largely reduced tumorigenic properties of cancer cells suggesting potential strategy for anticancer therapy.

Department of Histology and Embryology Faculty of Medicine Masaryk University Brno Czech Republic

Novosibirsk State University Novosibirsk Pirogova 2 630090 Russia

Translational Research in Cancer Stem Cells Vall d'Hebron Institut de Recerca Barcelona Spain

Translational Research in Cancer Stem Cells Vall d'Hebron Institut de Recerca Barcelona Spain; Novosibirsk Institute of Molecular Biology and Biophysics Novosibirsk Russia; ICRC FNUSA International Clinical Research Center and St Anne's University Hospital Brno Czech Republic

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