Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects - an explorative cross-sectional study
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
27719690
DOI
10.1017/s0031182016001785
PII: S0031182016001785
Knihovny.cz E-resources
- Keywords
- Toxoplasma gondii, Parasite, disease burden, neglected disease, neglected zoonosis, public health, toxoplasmosis,
- MeSH
- Adult MeSH
- Incidence MeSH
- Cohort Studies MeSH
- Humans MeSH
- Young Adult MeSH
- Parasite Load MeSH
- Antibodies, Protozoan blood MeSH
- Cross-Sectional Studies MeSH
- Risk Factors MeSH
- Seroepidemiologic Studies MeSH
- Case-Control Studies MeSH
- Toxoplasma immunology isolation & purification pathogenicity MeSH
- Toxoplasmosis complications epidemiology parasitology transmission MeSH
- Public Health MeSH
- Health Status * MeSH
- Animals MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antibodies, Protozoan MeSH
The global seroprevalence of latent toxoplasmosis is estimated to be higher than 30%. The presence of slowly dividing parasites in tissue cysts located mainly in immunoprivileged organs was long considered asymptomatic. Recently, many studies have shown that latent Toxoplasma infections could have serious impacts on human health. Here we ran a cross-sectional study in a population of 1486 volunteers. The results showed that 333 infected subjects scored worse than 1153 controls in 28 of 29 health-related variables. Similarly, they reported higher rates of 77 of a list of 134 disorders reported by at least 10 participants of the study. Toxoplasmosis was associated most strongly with musculoskeletal (τ = 0·107, P < 0·0005), followed by neurological (τ = 0·088, P < 0·0005), immune (τ = 0·085, p < 0·0005), metabolic (τ = 0·079, P < 0·0005), respiratory (τ = 0·068, P = 0·0001), allergic (τ = 0·053, P = 0·004), digestive system (τ = 0·052, P = 0·004) and mental health disorders (τ = 0·050, P = 0·008). Results of the present cohort study, along with the previous data from many case-control studies or ecological studies suggest that latent toxoplasmosis represents a large and so far underrated public health problem.
References provided by Crossref.org
Thirty years of studying latent toxoplasmosis: behavioural, physiological, and health insights
Le Petit Machiavellian Prince: Effects of Latent Toxoplasmosis on Political Beliefs and Values
Negative Effects of Latent Toxoplasmosis on Mental Health
Does Toxoplasma infection increase sexual masochism and submissiveness? Yes and no
