BACKGROUND: Since its discovery in the 1930s, the effects of Rh phenotype on human health and wellbeing, with the exception of the effects of Rh-negativity of a mother on the risk of hemolytic anemia of Rh-positive children, has only rarely been studied. In the last few years, however, several studies have shown that Rh-negative subjects have worse health and performance in certain tests than their Rh-positive peers. Nothing is known about the effect of Rh phenotype on the quality of life of subjects as measured by a standard instrument. METHODS: We hereby analyzed the data of 1768 male (24% Rh-negative) and 3759 female participants (23% Rh-negative) of an anonymous internet study using the partial Kendall test with the age and the population of the hometown of subjects controlled. RESULTS: The results showed that the Rh-negative women, but not men, scored worse in wellbeing measured with the WHO-BREFF. The Rh-negative men scored worse in mental health-related variables and in their reported economic situation and the Rh-negative women scored better in physical health-related variables. Both the Rh-negative men and women reported higher sexual activity than their Rh-positive peers. CONCLUSIONS: The effects of the Rh phenotype were significant after the correction for multiple tests. However, they were usually weaker and less numerous than those of smoking, consuming alcohol, and high body mass index, which were used as a sort of internal control.

Department of Applied Neurosciences and Brain Imagination National Institute of Mental Health Klecany Czech Republic

Department of Philosophy and History of Science Faculty of Science Charles University Prague Czech Republic

Department of Teaching and Didactics of Biology Faculty of Science Charles University Prague Czech Republic

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Wagner FF, Flegel WA (2000) RHD gene deletion occurred in the Rhesus box. Blood 95: 3662–3668. PubMed

Flegel WA (2011) Molecular genetics and clinical applications for RH. Transfusion and Apheresis Science 44: 81–91. 10.1016/j.transci.2010.12.013 PubMed DOI PMC

Kustu S, Inwood W (2006) Biological gas channels for NH3 and CO2: evidence that Rh (rhesus) proteins are CO2 channels. Transfusion Clinique et Biologique 13: 103–110. 10.1016/j.tracli.2006.03.001 PubMed DOI

Huang CH (2008) Molecular origin and variability of the Rh gene family: an overview of evolution, genetics and function. Hematology Education: the education programme for the annual congress of the European Hematology Association 2: 149–157.

Filbey D, Hanson U, Wesstrom G (1995) The prevalence of red cell antibodies in pregnancy correlated to the outcome of the newborn: a 12 year study in central Sweden. Acta Obstetrica and Gynecologica Scandinavica 74: 687–692. PubMed

Bowman J (1997) The management of hemolytic disease in the fetus and newborn. Seminars in Perinatology 21: 39–44. 10.1016/s0146-0005(97)80018-3 PubMed DOI

Feldman MW, Nabholz M, Bodmer WF (1969) Evolution of the Rh polymorphism: A model for the interaction of incompatibility, reproductive compensation and heterozygote advantage American Journal of Human Genetics 21: 171–193. PubMed PMC

Vermandois D (1992) An hypothesis about the selection of the Rh negative individuals. International Journal of Anthropology 7: 9–18.

Cattell R.B., Young H.B., Hundleby J.D. Blood groups and personality traits. American Journal of Human Genetics 16(4), 1964: 397–402. PubMed PMC

Novotná M, Havlíček J, Smith AP, Kolbeková P, Skallová A, et al. (2008) Toxoplasma and reaction time: Role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism. Parasitology 135: 1253–1261. 10.1017/S003118200800485X PubMed DOI

Flegr J, Novotná M, Lindová J, Havlíček J (2008) Neurophysiological effect of the Rh factor. Protective role of the RhD molecule against Toxoplasma-induced impairment of reaction times in women. Neuroendocrinology Letters 29: 475–481. PubMed

Flegr J, Geryk J, Volny J, Klose J, Cernochova D (2012) Rhesus factor modulation of effects of smoking and age on psychomotor performance, intelligence, personality profile, and health in Czech soldiers. PLoS ONE 7: e49478 10.1371/journal.pone.0049478 PubMed DOI PMC

Flegr J, Preiss M, Klose J (2013) Toxoplasmosis-associated difference in intelligence and personality in men depends on their Rhesus blood group but not ABO blood group. PLoS ONE 8. PubMed PMC

Flegr J, Sebankova B, Priplatova L, Chvatalova V, Kankova S (2018) Lower performance of Toxoplasma-infected, Rh-negative subjects in the weight holding and hand-grip tests. PLoS ONE 13. PubMed PMC

Kaňková Š, Šulc J, Flegr J (2010) Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effect. Parasitology 137: 1773–1779. 10.1017/S0031182010000661 PubMed DOI

Flegr J (2016) Heterozygote advantage probably maintains Rhesus factor blood group polymorphism: Ecological regression study. PLoS ONE 11. PubMed PMC

Flegr J, Hoffmann R, Dammann M (2015) Worse health status and higher incidence of health disorders in Rhesus negative subjects. PLoS ONE 10. PubMed PMC

Kankova S, Flegr J, Calda P (2015) The influence of latent toxoplasmosis on women's reproductive function: four cross-sectional studies. Folia Parasitologica 62. PubMed

Orley J, Harper A, Power M, Billington R (1997) Development of the WHOQOL-BREF quality of life assessment. Quality of Life Research 6: 273–273.

Dragomirecka E (2006) Czech version of the World Health Organization Quality of Life (WHOQOL)—translation and designing the response scales. Psychiatrie 10: 68–73.

R Core Team (2018) R: A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna. Austria.

Kim S (2015) ppcor: An R package for a fast calculation to semi-partial correlation coefficients. Communications for Statistical Applications and Methods 22: 665–674. 10.5351/CSAM.2015.22.6.665 PubMed DOI PMC

Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B-Methodological 57: 289–300.

Flegr J (2019) Data set for Effects of Rh negativity on wellbeing, health, fecundity, sexual desire, and sexual activity. Database: figshare [Internet]. Available from: 10.6084/m9.figshare.8216276.v1. DOI

Low BS, Simon CP, Anderson KG (2002) An evolutionary ecological perspective on demographic transitions: Modeling multiple currencies. American Journal of Human Biology 14: 149–167. 10.1002/ajhb.10043 PubMed DOI

Ellis BJ, Figueredo AJ, Brumbach BH, Schlomer GL (2009) Fundamental dimensions of environmental risk. Human Nature 20: 204–268. 10.1007/s12110-009-9063-7 PubMed DOI

Flegr J, Kuba R (2016) The relation of Toxoplasma infection and sexual attraction to fear, danger, pain, and submissiveness. Evolutionary Psychology 14.

Flegr J, Escudero DQ (2016) Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects—an explorative cross-sectional study. Parasitology 143: 1974–1989. 10.1017/S0031182016001785 PubMed DOI

Šebánková B, Flegr J (2017) Physical and mental health status in Toxoplasma-infected women before and three years after they learn about their infection: Manipulation or side-effects of impaired health? Frontiers in Ecology and Evolution 5: 144.

Frost P, Kleisner K, Flegr J (2017) Health status by gender, hair color, and eye color: Red-haired women are the most divergent. PLoS ONE 12. PubMed PMC

Flegr J, Horáček J (2017) Toxoplasma-infected subjects report an obsessive-compulsive disorder diagnosis more often and score higher in obsessive-compulsive inventory. European Psychiatry 40: 82–87. 10.1016/j.eurpsy.2016.09.001 PubMed DOI

Flegr J, Novotná M, Fialová A, Kolbeková P, Gašová Z (2010) The influence of RhD phenotype on toxoplasmosis- and age-associated changes in personality profile of blood donors. Folia Parasitologica 57: 143–150. PubMed

Halmin M, Rostgaard K, Lee BK, Wikman A, Norda R, et al. (2017) Length of storage of red blood cells and patient survival after blood transfusion a binational cohort study. Annals of Internal Medicine 166: 248–256. 10.7326/M16-1415 PubMed DOI

Cohen J (1977) Statistical power analysis for the behavioral sciences. New York, New York 10003: Academic Press Inc.

Redheaded women are more sexually active than other women, but it is probably due to their suitors

The importance of being heterozygote: effects of RHD-genotype-sex interaction on the physical and mental health of a non-clinical population

Toxoplasmosis is a risk factor for acquiring SARS-CoV-2 infection and a severe course of COVID-19 in the Czech and Slovak population: a preregistered exploratory internet cross-sectional study

Faster life history strategy manifests itself by lower age at menarche, higher sexual desire, and earlier reproduction in people with worse health

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