Heterozygote Advantage Probably Maintains Rhesus Factor Blood Group Polymorphism: Ecological Regression Study

. 2016 ; 11 (1) : e0147955. [epub] 20160126

Jazyk angličtina Země Spojené státy americké Médium electronic-ecollection

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid26811928

Rhesus factor polymorphism has been an evolutionary enigma since its discovery in 1939. Carriers of the rarer allele should be eliminated by selection against Rhesus positive children born to Rhesus negative mothers. Here I used an ecologic regression study to test the hypothesis that Rhesus factor polymorphism is stabilized by heterozygote advantage. The study was performed in 65 countries for which the frequencies of RhD phenotypes and specific disease burden data were available. I performed multiple multivariate covariance analysis with five potential confounding variables: GDP, latitude (distance from the equator), humidity, medical care expenditure per capita and frequencies of smokers. The results showed that the burden associated with many diseases correlated with the frequencies of particular Rhesus genotypes in a country and that the direction of the relation was nearly always the opposite for the frequency of Rhesus negative homozygotes and that of Rhesus positive heterozygotes. On the population level, a Rhesus-negativity-associated burden could be compensated for by the heterozygote advantage, but for Rhesus negative subjects this burden represents a serious problem.

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Wagner FF, Flegel WA (2000) RHD gene deletion occurred in the Rhesus box. Blood 95: 3662–3668. PubMed

Haldane JBS (1942) Selection against heterozygosis in Man. Eugenics 11: 333–340.

Hogben L (1943) Mutation and the Rhesus reaction. Nature 152: 721–722.

Fisher RA, Race RR, Taylor GL (1944) Mutation and the rhesus reaction. Nature 153: 106–106.

Li CC (1953) Is the Rh facing a crossroad? A critique of the compensation effect. American Naturalist 87: 257–261.

Feldman MW, Nabholz M, Bodmer WF (1969) Evolution of the Rh polymorphism: A model for the interaction of incompatibility, reproductive compensation and heterozygote advantage AmJHumGenet 21: 171–193. PubMed PMC

Novotná M, Havlíček J, Smith AP, Kolbeková P, Skallová A, et al. (2008) Toxoplasma and reaction time: Role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism. Parasitology 135: 1253–1261. 10.1017/S003118200800485X PubMed DOI

Flegr J, Novotná M, Lindová J, Havlíček J (2008) Neurophysiological effect of the Rh factor. Protective role of the RhD molecule against Toxoplasma-induced impairment of reaction times in women. Neuroendocrinology Letters 29: 475–481. PubMed

Flegr J, Klose J, Novotná M, Berenreitterová M, Havlíček J (2009) Increased incidence of traffic accidents in Toxoplasma-infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study. BMC Infectious Diseases 9: art. 72 10.1186/1471-2334-9-72 PubMed DOI PMC

Flegr J, Novotná M, Fialová A, Kolbeková P, Gašová Z (2010) The influence of RhD phenotype on toxoplasmosis- and age-associated changes in personality profile of blood donors. Folia Parasitologica 57: 143–150. PubMed

Flegr J, Preiss M, Klose J (2013) Toxoplasmosis-associated difference in intelligence and personality in men depends on their Rhesus blood group but not ABO blood group. PLoS ONE 8. PubMed PMC

Kaňková Š, Šulc J, Flegr J (2010) Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effect. Parasitology 137: 1773–1779. 10.1017/S0031182010000661 PubMed DOI

Flegr J, Geryk J, Volny J, Klose J, Cernochova D (2012) Rhesus factor modulation of effects of smoking and age on psychomotor performance, intelligence, personality profile, and health in Czech soldiers. PLoS ONE 7: e49478 10.1371/journal.pone.0049478 PubMed DOI PMC

Flegr J, Hoffmann R, Dammann M (2015) Worse health status and higher incidence of health disorders in Rhesus negative subjects. PLoS ONE 10(10): e0141362 10.1371/journal.pone.0141362 PubMed DOI PMC

Allison AC (1954) The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria- Protection afforded by sickle-cell trait against subtertian malareal infection. Trans R Soc Trop Med Hyg 48: 312–318. PubMed

Kustu S, Inwood W (2006) Biological gas channels for NH3 and CO2: evidence that Rh (rhesus) proteins are CO2 channels. Transfusion Clinique et Biologique 13: 103–110. PubMed

Flegel WA (2011) Molecular genetics and clinical applications for RH. Transfusion and Apheresis Science 44: 81–91. 10.1016/j.transci.2010.12.013 PubMed DOI PMC

Le Van Kim C, Colin Y, Cartron JP (2006) Rh proteins: Key structural and functional components of the red cell membrane. Blood Reviews 20: 93–110. PubMed

WHO (2008) The Global Burden of Disease: 2004 update. Geneva: World Health Organization.

Flegr J, Dama M (2014) Does prevalence of latent toxoplasmosis correlate with nation-wide rate of traffic accidents? Folia Parasitologica 6: 485–494. PubMed

Mourant AE (1954) The distribution of the human blood groups. Oxford: Blackwell Scientific Publication.

Flegr J, Prandota J, Sovickova M, Israili ZH (2014) Toxoplasmosis—A global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS ONE 9. PubMed PMC

Garcia LV (2004) Escaping the Bonferroni iron claw in ecological studies. Oikos 105: 657–663.

Wakefield J, Salway R (2001) A statistical framework for ecological and aggregate studies. Journal of the Royal Statistical Society: Series A (Statistics in Society) 164: 119–137.

Guthrie KA, Sheppard L (2001) Overcoming biases and misconceptions in ecological studies. Journal of the Royal Statistical Society: Series A (Statistics in Society) 164: 141–154.

Anstee DJ (2010) The relationship between blood groups and disease. Blood 115: 4635–4643. 10.1182/blood-2010-01-261859 PubMed DOI

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