Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effect
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20602855
DOI
10.1017/s0031182010000661
PII: S0031182010000661
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Weight Gain * MeSH
- Rh-Hr Blood-Group System blood immunology MeSH
- Humans MeSH
- Young Adult MeSH
- Infant, Newborn MeSH
- Pregnancy Complications, Parasitic blood parasitology physiopathology MeSH
- Birth Weight MeSH
- Pregnancy MeSH
- Body Weight MeSH
- Toxoplasma MeSH
- Toxoplasmosis blood parasitology physiopathology MeSH
- Ultrasonography, Prenatal MeSH
- Animals MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Rh-Hr Blood-Group System MeSH
- Rho(D) antigen MeSH Browser
OBJECTIVE: RhD-positive subjects are protected against toxoplasmosis-associated impairment of psychomotor performance. Here we searched for RhD-positivity-associated maternal protection against the effects of toxoplasmosis. METHODS: In the present retrospective cohort study, we analysed data from 785 (139 RhD-negative) Toxoplasma-free and 194 (27 RhD-negative) Toxoplasma-infected pregnant women. We searched for effects of toxoplasmosis and Rhd-phenotype on maternal weight before pregnancy, pregnancy weight gain, fetal ultrasound data (biparietal diameter, abdominal circumference, femur length) and on birth length and weight. RESULTS: At pregnancy week 16, the RhD-negative mothers with toxoplasmosis gained more weight than others (P < 0.001). The difference of about 1600 g remained approximately constant from pregnancy week 16 until the end of pregnancy. Neither toxoplasmosis nor RhD phenotype had any effect on fetal bioparameter data or birth length and weight. CONCLUSION: The most parsimonious explanation for the observed data is that the RhD-positive phenotype might protect infected subjects against a broad spectrum of detrimental effects of latent toxoplasmosis, including excessive gestational weight gain.
References provided by Crossref.org
Thirty years of studying latent toxoplasmosis: behavioural, physiological, and health insights
Latent toxoplasmosis and olfactory functions of Rh positive and Rh negative subjects
Worse Health Status and Higher Incidence of Health Disorders in Rhesus Negative Subjects
No Evidence of Association between Toxoplasma gondii Infection and Financial Risk Taking in Females