Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effect
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20602855
DOI
10.1017/s0031182010000661
PII: S0031182010000661
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- hmotnostní přírůstek * MeSH
- krevní skupiny - systém Rh-Hr krev imunologie MeSH
- lidé MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- parazitární komplikace těhotenství krev parazitologie patofyziologie MeSH
- porodní hmotnost MeSH
- těhotenství MeSH
- tělesná hmotnost MeSH
- Toxoplasma MeSH
- toxoplazmóza krev parazitologie patofyziologie MeSH
- ultrasonografie prenatální MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- krevní skupiny - systém Rh-Hr MeSH
- Rho(D) antigen MeSH Prohlížeč
OBJECTIVE: RhD-positive subjects are protected against toxoplasmosis-associated impairment of psychomotor performance. Here we searched for RhD-positivity-associated maternal protection against the effects of toxoplasmosis. METHODS: In the present retrospective cohort study, we analysed data from 785 (139 RhD-negative) Toxoplasma-free and 194 (27 RhD-negative) Toxoplasma-infected pregnant women. We searched for effects of toxoplasmosis and Rhd-phenotype on maternal weight before pregnancy, pregnancy weight gain, fetal ultrasound data (biparietal diameter, abdominal circumference, femur length) and on birth length and weight. RESULTS: At pregnancy week 16, the RhD-negative mothers with toxoplasmosis gained more weight than others (P < 0.001). The difference of about 1600 g remained approximately constant from pregnancy week 16 until the end of pregnancy. Neither toxoplasmosis nor RhD phenotype had any effect on fetal bioparameter data or birth length and weight. CONCLUSION: The most parsimonious explanation for the observed data is that the RhD-positive phenotype might protect infected subjects against a broad spectrum of detrimental effects of latent toxoplasmosis, including excessive gestational weight gain.
Citace poskytuje Crossref.org
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