Neurophysiological effect of the Rh factor. Protective role of the RhD molecule against Toxoplasma-induced impairment of reaction times in women
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
18766148
PII: NEL290408A04
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- krevní skupiny - systém Rh-Hr metabolismus MeSH
- lidé MeSH
- neuroprotektivní látky metabolismus MeSH
- novorozenec MeSH
- reakční čas fyziologie MeSH
- testosteron krev MeSH
- Toxoplasma metabolismus MeSH
- toxoplazmóza patofyziologie MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- krevní skupiny - systém Rh-Hr MeSH
- neuroprotektivní látky MeSH
- Rho(D) antigen MeSH Prohlížeč
- testosteron MeSH
BACKGROUND: The biological function of RhD protein, a major component of the Rh blood group system, is largely unknown. No phenotypic effect of RhD protein, except its role in hemolytic disease of newborns and protective role against Toxoplasma-induced impairment of reaction times in men, has been described. METHODS: Here we searched for a protective effect of RhD positivity against Toxoplasma-induced prolongation of reaction times in a set of 110 male and 226 female students of the Faculty of Science tested for latent toxoplasmosis and concentration of testosterone in saliva. RESULTS: RhD-positive subjects have been confirmed to be less sensitive to the influence of latent toxoplasmosis on reaction times than Rh-negative subjects. While a protective role of RhD positivity has been demonstrated previously in four populations of men, the present study has shown a similar effect in 226 female students. Our results have also shown that the concentration of testosterone in saliva strongly influences (reduces) reaction times (especially in men) and therefore, this factor should be controlled in future reaction times studies. CONCLUSIONS: The observed effects of RhD phenotype could provide not only a clue to the long-standing evolutionary enigma of the origin of RhD polymorphism in humans (the effect of balancing selection), differences in the RhD+ allele frequencies in geographically distinct populations (resulting from geographic variation in the prevalence of Toxoplasma gondii), but might also be the missing piece in the puzzle of the physiological function of the RhD molecule.
Latent toxoplasmosis and olfactory functions of Rh positive and Rh negative subjects
Worse Health Status and Higher Incidence of Health Disorders in Rhesus Negative Subjects
No Evidence of Association between Toxoplasma gondii Infection and Financial Risk Taking in Females