Toxoplasma-infected subjects report an Obsessive-Compulsive Disorder diagnosis more often and score higher in Obsessive-Compulsive Inventory
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
27992837
DOI
10.1016/j.eurpsy.2016.09.001
PII: S0924-9338(16)30135-3
Knihovny.cz E-resources
- Keywords
- Infection, Learning disabilities, Mental disorder, Parasites, Risk factors, Toxoplasmosis,
- MeSH
- Adult MeSH
- Cats MeSH
- Quality of Life MeSH
- Middle Aged MeSH
- Humans MeSH
- Statistics, Nonparametric MeSH
- Obsessive-Compulsive Disorder diagnosis parasitology psychology MeSH
- Cross-Sectional Studies MeSH
- Schizophrenia diagnosis parasitology MeSH
- Toxoplasma MeSH
- Toxoplasmosis complications transmission MeSH
- Animals MeSH
- Check Tag
- Adult MeSH
- Cats MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: Latent toxoplasmosis, the life-long presence of dormant stages of Toxoplasma in immunoprivileged organs and of anamnestic IgG antibodies in blood, affects about 30% of humans. Infected subjects have an increased incidence of various disorders, including schizophrenia. Several studies, as well as the character of toxoplasmosis-associated disturbance of neurotransmitters, suggest that toxoplasmosis could also play an etiological role in Obsessive-Compulsive Disorder (OCD). METHODS: The aim of the present cross-sectional study performed on a population of 7471 volunteers was to confirm the association between toxoplasmosis and OCD, and toxoplasmosis and psychological symptoms of OCD estimated by the standard Obsessive-Compulsive Inventory-Revised (OCI-R). RESULTS: Incidence of OCD was 2.18% (n=39) in men and 2.28% (n=83) in women. Subjects with toxoplasmosis had about a 2.5 times higher odds of OCD and about a 2.7 times higher odds of learning disabilities. The incidence of 18 other neuropsychiatric disorders did not differ between Toxoplasma-infected and Toxoplasma-free subjects. The infected subjects, even the OCD-free subjects, scored higher on the OCI-R. LIMITATIONS: Examined subjects provided the information about their toxoplasmosis and OCD statuses themselves, which could result in underrating the strength of observed associations. CONCLUSIONS: The results confirmed earlier reports of the association between toxoplasmosis and OCD. They also support recent claims that latent toxoplasmosis is in fact a serious disease with many impacts on quality of life of patients.
References provided by Crossref.org
Thirty years of studying latent toxoplasmosis: behavioural, physiological, and health insights
Skin fairness is a better predictor for impaired physical and mental health than hair redness
Negative Effects of Latent Toxoplasmosis on Mental Health
Latent toxoplasmosis and olfactory functions of Rh positive and Rh negative subjects
