Mixed epithelial and stromal tumor of the middle ear: The first case report
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
27746270
DOI
10.1016/j.humpath.2016.09.020
PII: S0046-8177(16)30244-1
Knihovny.cz E-resources
- Keywords
- Corpus albicans like scar, Head and neck, Middle ear, Mixed epithelial and stromal tumor, Ovarian stroma,
- MeSH
- Biopsy MeSH
- Stromal Cells chemistry pathology MeSH
- Molecular Diagnostic Techniques MeSH
- Epithelial Cells chemistry pathology MeSH
- Immunohistochemistry MeSH
- Humans MeSH
- Biomarkers, Tumor analysis genetics MeSH
- Neoplasms, Complex and Mixed chemistry genetics pathology surgery MeSH
- Ear Neoplasms chemistry genetics pathology surgery MeSH
- Tomography, X-Ray Computed MeSH
- Cell Proliferation MeSH
- Aged MeSH
- Ear, Middle chemistry pathology surgery MeSH
- Terminology as Topic MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers, Tumor MeSH
We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces were lined by flat, cuboidal, or columnar epithelial cells, in most parts showing mucinous differentiation. The epithelial lining of the cysts strongly expressed cytokeratins AE1-3, CK7, CK8, CK18, CK19, EMA, and S100 protein. The stroma expressed CD34 and smooth muscle actin. No cytological atypia or mitoses were present, and the proliferative activity was less than 1% in both components. The clonality analysis proved the clonal nature of the neoplasm. We believe that this tumor is a new member in the family of neoplasms containing the OS, and therefore we propose the term mixed epithelial and stromal tumor of the middle ear.
Bioptical Laboratory Ltd Pilsen Czech Republic 32600
Department of Pathology Faculty of Medicine in Pilsen Charles University Prague Czech Republic 30460
Department of Radiology Faculty of Medicine in Pilsen Charles University Czech Republic 30460
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