Differences in food intake and genetic variability in taste receptors between Czech pregnant women with and without gestational diabetes mellitus
Language English Country Germany Media print-electronic
Document type Journal Article
Grant support
16-28040A
Ministerstvo Zdravotnictví Ceské Republiky
PubMed
27757593
DOI
10.1007/s00394-016-1334-6
PII: 10.1007/s00394-016-1334-6
Knihovny.cz E-resources
- Keywords
- Dietary intake, Food preferences, Genetic variability, Gestational diabetes mellitus, Single nucleotide polymorphism, Taste receptors,
- MeSH
- Patient Compliance * MeSH
- Taste Receptors, Type 2 MeSH
- Adult MeSH
- Prenatal Nutritional Physiological Phenomena * MeSH
- Genetic Predisposition to Disease MeSH
- Genetic Association Studies MeSH
- Diabetes, Gestational diagnosis etiology genetics prevention & control MeSH
- Polymorphism, Single Nucleotide * MeSH
- Humans MeSH
- Food Preferences * MeSH
- Prenatal Diagnosis MeSH
- Receptors, G-Protein-Coupled genetics MeSH
- Case-Control Studies MeSH
- Pregnancy MeSH
- Diet, Western adverse effects MeSH
- Diet, Healthy * MeSH
- Self Report MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Czechoslovakia MeSH
- Names of Substances
- Taste Receptors, Type 2 MeSH
- Receptors, G-Protein-Coupled MeSH
- TAS2R7 protein, human MeSH Browser
- taste receptors, type 1 MeSH Browser
PURPOSE: Gestational diabetes mellitus (GDM) represents the most frequent metabolic disorder in pregnancy. Since dietary intake plays an important role in obesity and type 2 diabetes development, it is likely to be for the susceptibility to GDM too. Food preferences, driving partly the diet composition, are changing during pregnancy. Taste and genetic variability in taste receptors is an important factor in determining food preferences. Aims of our study were (1) to characterize dietary habits of pregnant women and to find possible differences in food preferences between healthy pregnant women and those with GDM and (2) to ascertain possible association of several single nucleotide polymorphisms (SNPs) in taste receptor (TR) genes with GDM. METHODS: A total of 363 pregnant women (293 with GDM and 70 with physiologic pregnancy) were included in the study. Dietary pattern spanning the period of approx. 6 months preceding the time of GDM screening was assessed using a semi-quantitative food frequency questionnaire. A total of five SNPs in TR genes were selected for genotyping based on their functionality or previous associations. RESULTS: Women with GDM exhibited significantly more frequent meat consumption (esp. poultry, pork and smoked meat), dairy products and sweet beverages consumption. The legumes consumption was found to be inversely correlated with fasting glycaemia (P = 0.007, Spearman). CC genotype in TAS2R9 gene (SNP rs3741845) was significantly associated with GDM (P = 0.0087, Chi-square test). CONCLUSIONS: Our study showed differences in dietary intake of selected food items between healthy pregnant women and those with GDM and genetic association of bitter taste receptor allele with GDM.
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