Cyanobacteria are physiologically and morphologically diverse photosynthetic microbes that play major roles in the carbon and nitrogen cycles of the biosphere. Recently, they have gained attention as potential platforms for the production of biofuels and other renewable chemicals. Many cyanobacteria were characterized morphologically prior to the advent of genome sequencing. Here, we catalog cyanobacterial ultrastructure within the context of genomic sequence information, including high-magnification transmission electron micrographs that represent the diversity in cyanobacterial morphology. We place the image data in the context of tabulated protein domains-which are the structural, functional, and evolutionary units of proteins-from the 126 cyanobacterial genomes comprising the CyanoGEBA dataset. In particular, we identify the correspondence between ultrastructure and the occurrence of genes encoding protein domains related to the formation of cyanobacterial inclusions. This compilation of images and genome-level domain occurrence will prove useful for a variety of analyses of cyanobacterial sequence data and provides a guidebook to morphological features.

Berkeley Synthetic Biology Institute UC Berkeley Berkeley CA USA

Bioinformatics Graduate Group University of California San Francisco CA 94158 USA

Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI USA

Department of Biology Faculty of Medicine Masaryk University University Campus Building A6 Kamenice 5 625 00 Brno Czech Republic

Department of Plant and Microbial Biology UC Berkeley Berkeley CA USA

Institut de Biologie de l'ENS IBENS Inserm U1024 CNRS UMR 8197 Ecole Normale Supérieure 75005 Paris France

MSU DOE Plant Research Laboratory Michigan State University East Lansing MI USA

Physical Biosciences Division Lawrence Berkeley National Laboratory Berkeley CA USA

Unité des Cyanobactéries Institut Pasteur Centre National de la Recherche Scientifique 2172 75724 Paris Cedex 15 France

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