Cyanobacteria are physiologically and morphologically diverse photosynthetic microbes that play major roles in the carbon and nitrogen cycles of the biosphere. Recently, they have gained attention as potential platforms for the production of biofuels and other renewable chemicals. Many cyanobacteria were characterized morphologically prior to the advent of genome sequencing. Here, we catalog cyanobacterial ultrastructure within the context of genomic sequence information, including high-magnification transmission electron micrographs that represent the diversity in cyanobacterial morphology. We place the image data in the context of tabulated protein domains-which are the structural, functional, and evolutionary units of proteins-from the 126 cyanobacterial genomes comprising the CyanoGEBA dataset. In particular, we identify the correspondence between ultrastructure and the occurrence of genes encoding protein domains related to the formation of cyanobacterial inclusions. This compilation of images and genome-level domain occurrence will prove useful for a variety of analyses of cyanobacterial sequence data and provides a guidebook to morphological features.

Berkeley Synthetic Biology Institute UC Berkeley Berkeley CA USA

Bioinformatics Graduate Group University of California San Francisco CA 94158 USA

Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI USA

Department of Biology Faculty of Medicine Masaryk University University Campus Building A6 Kamenice 5 625 00 Brno Czech Republic

Department of Plant and Microbial Biology UC Berkeley Berkeley CA USA

Institut de Biologie de l'ENS IBENS Inserm U1024 CNRS UMR 8197 Ecole Normale Supérieure 75005 Paris France

MSU DOE Plant Research Laboratory Michigan State University East Lansing MI USA

Physical Biosciences Division Lawrence Berkeley National Laboratory Berkeley CA USA

Unité des Cyanobactéries Institut Pasteur Centre National de la Recherche Scientifique 2172 75724 Paris Cedex 15 France

See more in PubMed

Palaeontology. 2015 Sep;58(5):769-785 PubMed

Photosynth Res. 2013 Nov;118(1-2):37-49 PubMed

Annu Rev Microbiol. 1968;22:15-46 PubMed

Curr Opin Struct Biol. 2004 Apr;14(2):208-16 PubMed

BMC Evol Biol. 2011 Feb 14;11:45 PubMed

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):10933-8 PubMed

Genome Biol. 2003;4(3):209 PubMed

Annu Rev Microbiol. 1984;38:1-25 PubMed

Arch Microbiol. 2014 Dec;196(12):881-90 PubMed

J Bacteriol. 2007 Jun;189(12):4485-93 PubMed

BMC Genomics. 2012 Feb 02;13:56 PubMed

J Exp Bot. 2013 Jan;64(3):753-68 PubMed

Curr Opin Plant Biol. 2016 Jun;31:66-75 PubMed

Science. 2012 Sep 21;337(6101):1546-50 PubMed

J Bacteriol. 1969 Mar;97(3):1486-93 PubMed

Nucleic Acids Res. 2014 Jan;42(Database issue):D222-30 PubMed

J Biotechnol. 2012 Nov 30;162(1):50-6 PubMed

J Biophys Biochem Cytol. 1961 Jan;9:63-80 PubMed

J Biophys Biochem Cytol. 1958 Nov 25;4(6):671-8 PubMed

Plant Physiol. 2011 Apr;155(4):1656-66 PubMed

PLoS One. 2014 Mar 17;9(3):e91524 PubMed

Nucleic Acids Res. 2012 Jan;40(Database issue):D306-12 PubMed

Annu Rev Microbiol. 1977;31:225-74 PubMed

J Lipid Res. 2012 Feb;53(2):215-26 PubMed

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1053-8 PubMed

DNA Res. 1996 Jun 30;3(3):109-36 PubMed

Nucleic Acids Res. 2012 Jan;40(Database issue):D115-22 PubMed

Trends Microbiol. 2015 Oct;23(10):642-52 PubMed

J Exp Bot. 2013 Jan;64(3):787-98 PubMed

Curr Opin Microbiol. 2011 Oct;14(5):608-14 PubMed

Arch Microbiol. 2001 Jul;176(1-2):9-18 PubMed

Science. 2010 Jul 30;329(5991):559-62 PubMed

DNA Res. 2001 Oct 31;8(5):205-13; 227-53 PubMed

J Pharmacol Exp Ther. 2001 May;297(2):704-10 PubMed

Microbiol Rev. 1994 Mar;58(1):94-144 PubMed

Evolutionary Patterns of Thylakoid Architecture in Cyanobacteria