Homocysteine and Real-Space Navigation Performance among Non-Demented Older Adults
Language English Country United States Media print
Document type Journal Article
PubMed
27802238
DOI
10.3233/jad-160667
PII: JAD160667
Knihovny.cz E-resources
- Keywords
- APOE, Alzheimer’s disease, homocysteine, mild cognitive impairment, spatial navigation, subjective cognitive decline, vascular factors,
- MeSH
- Maze Learning physiology MeSH
- Discrimination, Psychological MeSH
- Homocysteine blood MeSH
- Cognitive Dysfunction blood physiopathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Spatial Navigation physiology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Auditory Perception physiology MeSH
- Aging blood physiology MeSH
- Case-Control Studies MeSH
- Mental Status Schedule MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Homocysteine MeSH
BACKGROUND: High plasma homocysteine (Hcy) level is related to higher risk of Alzheimer's disease (AD) and lower cognitive performance in older adults. OBJECTIVE: To assess the association between plasma Hcy level and real-space navigation performance and the role of vascular risk and protective factors, APOE status, and white matter lesions (WML) on this association. METHODS: Ninety-two non-demented older adults (29 with amnestic mild cognitive impairment, 46 with subjective cognitive decline, and 17 cognitively normal older adults) underwent spatial navigation testing of egocentric, allocentric, and mixed navigation in a real-space analogue of the Morris water maze, neuropsychological examination, blood collection, and MRI brain scan with evaluation of WML. RESULTS: In the regression analyses controlling for age, gender, education, and depressive symptoms, higher plasma Hcy level was related to worse mixed and egocentric (β= 0.31; p = 0.003 and β= 0.23; p = 0.017) but not allocentric (p > 0.05) navigation performance. Additional controlling for vascular risk and protective factors, WML, and APOE status did not modify the results. High total cholesterol and low vitamin B12 and folate levels increased the adverse effect of Hcy on egocentric and mixed navigation. WML did not explain the association between plasma Hcy level and navigation performance. CONCLUSION: Elevated plasma Hcy level may affect real-space navigation performance above and beyond vascular brain changes. This association may be magnified in the presence of high total cholesterol and low folate or vitamin B12 levels. Attention to the level of plasma Hcy may be a viable intervention strategy to prevent decline in spatial navigation in non-demented older adults.
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
School of Aging Studies University of South Florida Tampa FL USA
References provided by Crossref.org
Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype
