Serial measurement of presepsin, procalcitonin, and C-reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation
Language English Country Denmark Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
27859613
DOI
10.1111/ctr.12870
Knihovny.cz E-resources
- Keywords
- C-reactive protein, antithymocyte globulin, heart transplantation, postoperative sepsis, presepsin, procalcitonin,
- MeSH
- Antilymphocyte Serum administration & dosage MeSH
- Biomarkers metabolism MeSH
- C-Reactive Protein metabolism MeSH
- Adult MeSH
- Immunosuppressive Agents administration & dosage MeSH
- Communicable Diseases drug therapy etiology metabolism MeSH
- Calcitonin metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipopolysaccharide Receptors metabolism MeSH
- Follow-Up Studies MeSH
- Peptide Fragments metabolism MeSH
- Postoperative Complications drug therapy etiology metabolism MeSH
- Graft Survival drug effects MeSH
- Prognosis MeSH
- Risk Factors MeSH
- Case-Control Studies MeSH
- Heart Transplantation adverse effects MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antilymphocyte Serum MeSH
- Biomarkers MeSH
- C-Reactive Protein MeSH
- Immunosuppressive Agents MeSH
- Calcitonin MeSH
- Lipopolysaccharide Receptors MeSH
- Peptide Fragments MeSH
- presepsin protein, human MeSH Browser
Differentiation between systemic inflammatory response syndrome and sepsis in surgical patients is of crucial significance. Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers, but PCT becomes compromised after antithymocyte globulin (ATG) administration, and CRP exhibits limited specificity. Presepsin has been suggested as an alternative biomarker of sepsis. This study aimed to demonstrate the role of presepsin in patients after heart transplantation (HTx). Plasma presepsin, PCT, and CRP were measured in 107 patients serially for up to 10 days following HTx. Time responses of biomarkers were evaluated for both noninfected (n=91) and infected (n=16) patients. Areas under the concentration curve differed in the two groups of patients for presepsin (P<.001), PCT (P<.005), and CRP (P<.001). The effect of time and infection was significant for all three biomarkers (P<.05 all). In contrast to PCT, presepsin was not influenced by ATG administration. More than 25% of noninfected patients had PCT above 42 μg/L on the first day, and the peak concentration of CRP in infected patients was reached on the third post-transplant day (median 135 mg/L). Presepsin seems to be as valuable a biomarker as PCT or CRP in the evaluation of infectious complications in patients after HTx.
3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic
References provided by Crossref.org
Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients
