Serial measurement of presepsin, procalcitonin, and C-reactive protein in the early postoperative period and the response to antithymocyte globulin administration after heart transplantation
Jazyk angličtina Země Dánsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
27859613
DOI
10.1111/ctr.12870
Knihovny.cz E-zdroje
- Klíčová slova
- C-reactive protein, antithymocyte globulin, heart transplantation, postoperative sepsis, presepsin, procalcitonin,
- MeSH
- antilymfocytární sérum aplikace a dávkování MeSH
- biologické markery metabolismus MeSH
- C-reaktivní protein metabolismus MeSH
- dospělí MeSH
- imunosupresiva aplikace a dávkování MeSH
- infekční nemoci farmakoterapie etiologie metabolismus MeSH
- kalcitonin metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipopolysacharidové receptory metabolismus MeSH
- následné studie MeSH
- peptidové fragmenty metabolismus MeSH
- pooperační komplikace farmakoterapie etiologie metabolismus MeSH
- přežívání štěpu účinky léků MeSH
- prognóza MeSH
- rizikové faktory MeSH
- studie případů a kontrol MeSH
- transplantace srdce škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antilymfocytární sérum MeSH
- biologické markery MeSH
- C-reaktivní protein MeSH
- imunosupresiva MeSH
- kalcitonin MeSH
- lipopolysacharidové receptory MeSH
- peptidové fragmenty MeSH
- presepsin protein, human MeSH Prohlížeč
Differentiation between systemic inflammatory response syndrome and sepsis in surgical patients is of crucial significance. Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers, but PCT becomes compromised after antithymocyte globulin (ATG) administration, and CRP exhibits limited specificity. Presepsin has been suggested as an alternative biomarker of sepsis. This study aimed to demonstrate the role of presepsin in patients after heart transplantation (HTx). Plasma presepsin, PCT, and CRP were measured in 107 patients serially for up to 10 days following HTx. Time responses of biomarkers were evaluated for both noninfected (n=91) and infected (n=16) patients. Areas under the concentration curve differed in the two groups of patients for presepsin (P<.001), PCT (P<.005), and CRP (P<.001). The effect of time and infection was significant for all three biomarkers (P<.05 all). In contrast to PCT, presepsin was not influenced by ATG administration. More than 25% of noninfected patients had PCT above 42 μg/L on the first day, and the peak concentration of CRP in infected patients was reached on the third post-transplant day (median 135 mg/L). Presepsin seems to be as valuable a biomarker as PCT or CRP in the evaluation of infectious complications in patients after HTx.
3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic
Citace poskytuje Crossref.org
Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients
