Distinct functions of human RecQ helicases during DNA replication
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
27876204
DOI
10.1016/j.bpc.2016.11.005
PII: S0301-4622(16)30348-9
Knihovny.cz E-zdroje
- Klíčová slova
- Cancer, DNA replication, Genomic instability, RecQ helicases, Replication stress,
- MeSH
- helikasy RecQ fyziologie MeSH
- lidé MeSH
- nádory etiologie MeSH
- nestabilita genomu MeSH
- replikace DNA * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- helikasy RecQ MeSH
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefore it is tightly controlled and coordinated with processes that maintain genomic stability. Human RecQ helicases are among the most important factors involved in the maintenance of replication fork integrity, especially under conditions of replication stress. RecQ helicases promote recovery of replication forks being stalled due to different replication roadblocks of either exogenous or endogenous source. They prevent generation of aberrant replication fork structures and replication fork collapse, and are involved in proper checkpoint signaling. The essential role of human RecQ helicases in the genome maintenance during DNA replication is underlined by association of defects in their function with cancer predisposition.
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