Distinct functions of human RecQ helicases during DNA replication
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
27876204
DOI
10.1016/j.bpc.2016.11.005
PII: S0301-4622(16)30348-9
Knihovny.cz E-resources
- Keywords
- Cancer, DNA replication, Genomic instability, RecQ helicases, Replication stress,
- MeSH
- RecQ Helicases physiology MeSH
- Humans MeSH
- Neoplasms etiology MeSH
- Genomic Instability MeSH
- DNA Replication * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- RecQ Helicases MeSH
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefore it is tightly controlled and coordinated with processes that maintain genomic stability. Human RecQ helicases are among the most important factors involved in the maintenance of replication fork integrity, especially under conditions of replication stress. RecQ helicases promote recovery of replication forks being stalled due to different replication roadblocks of either exogenous or endogenous source. They prevent generation of aberrant replication fork structures and replication fork collapse, and are involved in proper checkpoint signaling. The essential role of human RecQ helicases in the genome maintenance during DNA replication is underlined by association of defects in their function with cancer predisposition.
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