Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, přehledy
PubMed
27884721
DOI
10.1016/j.tox.2016.11.014
PII: S0300-483X(16)30293-1
Knihovny.cz E-zdroje
- Klíčová slova
- Comparison, Detoxification, Drug, Model organism, Pollution,
- MeSH
- druhová specificita MeSH
- lidé MeSH
- myši MeSH
- prasata MeSH
- ryby MeSH
- systém (enzymů) cytochromů P-450 genetika metabolismus MeSH
- xenobiotika metabolismus toxicita MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- srovnávací studie MeSH
- Názvy látek
- systém (enzymů) cytochromů P-450 MeSH
- xenobiotika MeSH
Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure to xenobiotics depend heavily on the expression and activity of drug-metabolizing CYP450s, which is determined by species, genetic background, age, gender, diet, and exposure to environmental pollutants. Numerous reports have investigated the role of different vertebrate CYP450s in xenobiotic metabolism. Model organisms provide powerful experimental tools to investigate Phase I metabolism. The aim of the present review is to compare the existing data on human CYP450 proteins (1-3 families) with those found in pigs, mice, and fish. We will highlight differences and similarities and identify research gaps which need to be addressed in order to use these species as models that mimic human traits. Moreover, we will discuss the roles of nuclear receptors in the cellular regulation of CYP450 expression in select organisms.
Citace poskytuje Crossref.org
Porcine cytochrome 2A19 and 2E1
