Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450
Language English Country Ireland Media print-electronic
Document type Comparative Study, Journal Article, Review
PubMed
27884721
DOI
10.1016/j.tox.2016.11.014
PII: S0300-483X(16)30293-1
Knihovny.cz E-resources
- Keywords
- Comparison, Detoxification, Drug, Model organism, Pollution,
- MeSH
- Species Specificity MeSH
- Humans MeSH
- Mice MeSH
- Swine MeSH
- Fishes MeSH
- Cytochrome P-450 Enzyme System genetics metabolism MeSH
- Xenobiotics metabolism toxicity MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Comparative Study MeSH
- Names of Substances
- Cytochrome P-450 Enzyme System MeSH
- Xenobiotics MeSH
Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure to xenobiotics depend heavily on the expression and activity of drug-metabolizing CYP450s, which is determined by species, genetic background, age, gender, diet, and exposure to environmental pollutants. Numerous reports have investigated the role of different vertebrate CYP450s in xenobiotic metabolism. Model organisms provide powerful experimental tools to investigate Phase I metabolism. The aim of the present review is to compare the existing data on human CYP450 proteins (1-3 families) with those found in pigs, mice, and fish. We will highlight differences and similarities and identify research gaps which need to be addressed in order to use these species as models that mimic human traits. Moreover, we will discuss the roles of nuclear receptors in the cellular regulation of CYP450 expression in select organisms.
References provided by Crossref.org
Porcine cytochrome 2A19 and 2E1
