Mitochondrial adaptations in aged skeletal muscle: effect of exercise training
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Review
PubMed
27982690
DOI
10.33549/physiolres.933329
PII: 933329
Knihovny.cz E-resources
- MeSH
- Exercise physiology MeSH
- Physical Endurance physiology MeSH
- Adaptation, Physiological physiology MeSH
- Muscle, Skeletal metabolism MeSH
- Humans MeSH
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha metabolism MeSH
- Aging metabolism MeSH
- Mitochondria, Muscle metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- PPARGC1A protein, human MeSH Browser
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha MeSH
The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in the elderly. However, recent studies have demonstrated that resistance training lead also to substantial increases in mitochondrial function in skeletal muscle. A comprehensive understanding of the cellular mechanisms involved in the skeletal muscle mitochondrial adaptations to exercise training in healthy elderly subjects, can help practitioners to design and prescribe more effective exercise trainings.
References provided by Crossref.org
Current progress in the therapeutic options for mitochondrial disorders