Long-Term Effect of Adrenalectomy on Cardiovascular Remodeling in Patients With Pheochromocytoma
Language English Country United States Media print
Document type Journal Article
PubMed
28001459
DOI
10.1210/jc.2016-2422
Knihovny.cz E-resources
- MeSH
- Adrenalectomy * MeSH
- Adult MeSH
- Essential Hypertension MeSH
- Pheochromocytoma surgery MeSH
- Outcome Assessment, Health Care * MeSH
- Hypertension complications MeSH
- Carotid Intima-Media Thickness * MeSH
- Middle Aged MeSH
- Humans MeSH
- Adrenal Gland Neoplasms surgery MeSH
- Follow-Up Studies MeSH
- Carotid Artery Diseases diagnostic imaging MeSH
- Ventricular Remodeling * MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
CONTEXT: Catecholamines may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial and myocardial wall due to various mechanisms. Reversibility of this process has not been studied on both structures simultaneously. OBJECTIVE: To clarify the long-term effect of excess normalization of catecholamines on carotid and myocardial wall changes in patients with pheochromocytoma or functional paraganglioma (PHEO) after tumor removal. DESIGN, SETTINGS, AND PATIENTS: Carotid intima-media thickness (IMT) and the left ventricular (LV) mass index were studied in 50 patients with PHEO before tumor removal and 5 years after tumor removal, and in 50 blood pressure- and age-matched essential hypertensive patients before follow-up and after 5 years of follow-up. MAIN OUTCOME MEASURES: Common carotid artery (CCA)-IMT and LV mass indexed to lean body mass (LBM). RESULTS: Elimination of catecholamine excess in the PHEO group resulted in a significant decrease in CCA-IMT and LV mass index from 0.86 ± 0.17 to 0.83 ± 0.18 mm (P < 0.05) and from 3.2 ± 0.9 to 2.9 ± 0.9 g/LBM (P < 0.001), respectively. In contrast, CCA-IMT and LV mass index increased significantly from 0.78 ± 0.14 to 0.81 ± 0.15 mm (P < 0.05) and from 3.1 ± 0.7 to 3.2 ± 0.6 g/LBM (P < 0.05), respectively, in patients with essential hypertension. CONCLUSION: In patients with PHEO, carotid IMT and LV mass index can significantly regress after tumor removal, in contrast to the impairment of these parameters in essential hypertensive patients during the same long-term period.
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