Central sensitization-related changes of effective and functional connectivity in the rat inflammatory trigeminal pain model
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
28003158
DOI
10.1016/j.neuroscience.2016.12.018
PII: S0306-4522(16)30708-4
Knihovny.cz E-resources
- Keywords
- central sensitization, effective connectivity, fMRI, functional connectivity, rodent pain model,
- MeSH
- Chronic Pain diagnostic imaging physiopathology MeSH
- Gyrus Cinguli diagnostic imaging physiopathology MeSH
- Trigeminal Ganglion physiopathology MeSH
- Oxygen blood MeSH
- Magnetic Resonance Imaging MeSH
- Brain Mapping MeSH
- Disease Models, Animal MeSH
- Cerebrovascular Circulation physiology MeSH
- Neural Pathways diagnostic imaging physiopathology MeSH
- Trigeminal Nerve physiopathology MeSH
- Rats, Sprague-Dawley MeSH
- Central Nervous System Sensitization physiology MeSH
- Vibrissae physiology MeSH
- Inflammation diagnostic imaging physiopathology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Oxygen MeSH
Central sensitization is a key mechanism in the pathology of several neuropathic pain disorders. We aimed to investigate the underlying brain connectivity changes in a rat model of chronic pain. Non-noxious whisker stimulation was used to evoke blood-oxygen-level-dependent (BOLD) responses in a block-design functional Magnetic Resonance Imaging (fMRI) experiment on 9.4T. Measurements were repeated two days and one week after injecting complete Freund's adjuvant into the rats' whisker pad. We found that acute pain reduced activation in the barrel cortex, most probably due to a plateau effect. After one week, increased activation of the anterior cingulate cortex was found. Analyses of effective connectivity driven by stimulus-related activation revealed that chronic pain-related central sensitization manifested as a widespread alteration in the activity of the somatosensory network. Changes were mainly mediated by the anterior cingulate cortex and the striatum and affected the somatosensory and motor cortices and the superior colliculus. Functional connectivity analysis of nested BOLD oscillations justified that the anterior cingular-somatosensory interplay is a key element of network changes. Additionally, a decreased cingulo-motor functional connectivity implies that alterations also involve the output tract of the network. Our results extend the knowledge about the role of the cingulate cortex in the chronification of pain and indicate that integration of multiple connectivity analysis could be fruitful in studying the central sensitization in the pain matrix.
Department of Nuclear Medicine University of Debrecen Debrecen Hungary
Preclinical Imaging Center Gedeon Richter Plc Budapest Hungary
References provided by Crossref.org
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