Obesity is accompanied by the development of chronic low-grade inflammation in adipose tissue. The presence of chronic inflammatory response along with metabolically harmful factors released by adipose tissue into the circulation is associated with several metabolic complications of obesity such as type 2 diabetes mellitus or accelerated atherosclerosis. The present review is focused on macrophages and lymphocytes and their possible role in low-grade inflammation in fat. Both macrophages and lymphocytes respond to obesity-induced adipocyte hypertrophy by their migration into adipose tissue. After activation and differentiation, they contribute to the development of local inflammatory response and modulation of endocrine function of adipose tissue. Despite intensive research, the exact role of lymphocytes and macrophages within adipose tissue is only partially clarified and various data obtained by different approaches bring ambiguous information with respect to their polarization and cytokine production. Compared to immunocompetent cells, the role of adipocytes in the obesity-related adipose tissue inflammation is often underestimated despite their abundant production of factors with immunomodulatory actions such as cytokines or adipokines such as leptin, adiponektin, and others. In summary, conflicting evidence together with only partial correlation of in vitro findings with true in vivo situation due to great heterogeneity and molecular complexity of tissue environment calls for intensive research in this rapidly evolving and important area.

Centre of Experimental Medicine Institute for Clinical and Experimental Medicine Prague Czech Republic

Department of Obesitology Institute of Endocrinology Prague Czech Republic

Diabetes Centre Institute for Clinical and Experimental Medicine Prague Czech Republic

Institute of Medical Biochemistry and Laboratory Diagnostics 1st Faculty of Medicine Charles University Prague and General University Hospital Prague Czech Republic

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J Biol Chem. 2011 Jan 21;286(3):1786-94 PubMed

Can J Physiol Pharmacol. 1997 Jul;75(7):789-95 PubMed

Nat Med. 2009 Aug;15(8):914-20 PubMed

Biochem Biophys Res Commun. 2010 Jan 15;391(3):1443-8 PubMed

J Lipid Res. 2005 Nov;46(11):2347-55 PubMed

Int J Obes (Lond). 2016 Jun;40(6):912-20 PubMed

FASEB J. 2017 Mar;31(3):868-881 PubMed

J Immunol. 2012 Mar 15;188(6):2592-601 PubMed

J Immunol. 1993 Jun 15;150(12):5576-84 PubMed

Nat Rev Immunol. 2012 Feb 17;12(3):180-90 PubMed

F1000Prime Rep. 2014 Mar 03;6:13 PubMed

N Engl J Med. 2003 Apr 24;348(17):1625-38 PubMed

Biochem Biophys Res Commun. 2005 Sep 9;334(4):1092-101 PubMed

Biochem Biophys Res Commun. 2004 Oct 15;323(2):630-5 PubMed

J Clin Invest. 2012 Mar;122(3):787-95 PubMed

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18336-41 PubMed

Diabetologia. 2016 Mar;59(3):560-70 PubMed

FEBS Lett. 2005 Jul 4;579(17):3487-92 PubMed

J Exp Med. 1989 Dec 1;170(6):2081-95 PubMed

Diabetes. 2012 Feb;61(2):346-54 PubMed

Science. 1995 Jul 28;269(5223):543-6 PubMed

Nature. 1998 Aug 27;394(6696):897-901 PubMed

Am J Physiol. 1998 Jan;274(1 Pt 2):R204-8 PubMed

Cell Metab. 2013 Oct 22;:null PubMed

Immunobiology. 2014 Sep;219(9):695-703 PubMed

J Immunol. 1989 Nov 1;143(9):2806-13 PubMed

J Virol. 2000 May;74(10):4729-37 PubMed

J Immunol. 2012 Feb 1;188(3):1178-90 PubMed

Diabetes. 2001 Oct;50(10):2199-202 PubMed

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E289-304 PubMed

J Immunol. 2002 Apr 1;168(7):3536-42 PubMed

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19446-51 PubMed

Circ Res. 1998 Nov 16;83(10):1059-66 PubMed

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1304-10 PubMed

Science. 2007 Aug 3;317(5838):666-70 PubMed

Nucleic Acids Res. 2012 Feb;40(4):1609-20 PubMed

Sci Signal. 2015 Mar 17;8(368):ra28 PubMed

Metabolism. 2008 Apr;57(4):488-93 PubMed

Nat Immunol. 2015 Jan;16(1):85-95 PubMed

Altern Med Rev. 2003 Aug;8(3):223-46 PubMed

Biomark Res. 2014 Jan 07;2(1):1 PubMed

FASEB J. 2006 Jul;20(9):1540-2 PubMed

J Innate Immun. 2010;2(4):316-24 PubMed

Biochem Biophys Res Commun. 2006 Dec 15;351(2):376-82 PubMed

Int J Obes (Lond). 2015 May;39(5):782-90 PubMed

J Nutr. 2004 Oct;134(10):2673-7 PubMed

Immunity. 2013 Apr 18;38(4):792-804 PubMed

Diabetes. 2004 May;53(5):1285-92 PubMed

JAMA. 2003 Jan 1;289(1):76-9 PubMed

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E740-7 PubMed

J Cell Physiol. 2011 Aug;226(8):2181-8 PubMed

Biochem Biophys Res Commun. 2003 Jan 10;300(2):472-6 PubMed

Circ Res. 2008 Aug 29;103(5):467-76 PubMed

Circulation. 2007 Feb 27;115(8):1029-38 PubMed

Nature. 1999 Jul 22;400(6742):378-82 PubMed

BMJ. 2000 Aug 12;321(7258):424 PubMed

Inflamm Bowel Dis. 1999 Nov;5(4):285-94 PubMed

J Clin Endocrinol Metab. 2001 Aug;86(8):3815-9 PubMed

Clin Chim Acta. 2013 Feb 18;417:80-4 PubMed

J Immunol. 2001 Feb 15;166(4):2173-7 PubMed

Int J Obes (Lond). 2011 Jan;35(1):91-8 PubMed

Endocrinology. 2011 Oct;152(10):3769-78 PubMed

Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1220-5 PubMed

J Exp Med. 2010 Feb 15;207(2):391-404 PubMed

Int J Obes (Lond). 2007 Sep;31(9):1420-8 PubMed

Sci Rep. 2011;1:76 PubMed

Nature. 2007 Jul 5;448(7149):44-9 PubMed

Angiogenesis. 2014 Jan;17 (1):109-18 PubMed

Cell Metab. 2013 Mar 5;17(3):411-22 PubMed

PLoS Comput Biol. 2009 Mar;5(3):e1000324 PubMed

Cell Metab. 2014 Jan 7;19(1):162-171 PubMed

Horm Metab Res. 2013 Sep;45(10):741-7 PubMed

Blood. 2006 Jun 15;107(12):4930-7 PubMed

In Vitro Cell Dev Biol Anim. 2013 Jun;49(6):473-8 PubMed

Physiol Res. 2004;53(2):123-9 PubMed

Gynecol Endocrinol. 2009 Apr;25(4):258-63 PubMed

Circulation. 1999 Dec 21-28;100(25):2473-6 PubMed

J Lipid Res. 1989 Dec;30(12):1917-23 PubMed

Nature. 2001 Jan 18;409(6818):307-12 PubMed

Cell Metab. 2016 Apr 12;23 (4):685-98 PubMed

PLoS One. 2015 Apr 20;10(3):e0122872 PubMed

Mol Cell Biochem. 2014 Mar;388(1-2):203-10 PubMed

Diabetes. 2010 May;59(5):1171-81 PubMed

Diabetes. 2014 Aug;63(8):2751-60 PubMed

Clin Dev Immunol. 2012;2012:925135 PubMed

Immunity. 2014 Apr 17;40(4):569-81 PubMed

Diabetologia. 2005 Nov;48(11):2330-3 PubMed

J Immunol. 2007 Feb 1;178(3):1748-58 PubMed

Diabetes. 2016 Sep;65(9):2516-28 PubMed

Diabetes. 2009 Nov;58(11):2525-35 PubMed

Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E1118-28 PubMed

J Immunol. 1995 May 15;154(10):5492-9 PubMed

Proc Natl Acad Sci U S A. 1994 May 24;91(11):4854-8 PubMed

Science. 1996 Nov 22;274(5291):1379-83 PubMed

Infect Immun. 2012 Dec;80(12):4426-34 PubMed

Nat Med. 2001 Aug;7(8):941-6 PubMed

J Biol Chem. 2012 Oct 26;287(44):36896-904 PubMed

Diabetologia. 2009 Jun;52(6):1152-63 PubMed

FASEB J. 1998 Jan;12(1):57-65 PubMed

J Exp Med. 2004 Jun 7;199(11):1455-65 PubMed

Proc Natl Acad Sci U S A. 1995 Apr 11;92 (8):3348-52 PubMed

Vitam Horm. 2006;74:443-77 PubMed

Breast Cancer Res Treat. 2012 Feb;131(3):1003-12 PubMed

Endocrinology. 2010 Sep;151(9):4247-56 PubMed

Nat Immunol. 2015 Apr;16(4):376-85 PubMed

J Immunol. 1993 Nov 1;151(9):4545-51 PubMed

Eur J Immunol. 2008 Sep;38(9):2573-86 PubMed

J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56 PubMed

Immunity. 2011 Apr 22;34(4):566-78 PubMed

Circulation. 2008 Feb 12;117(6):806-15 PubMed

J Immunol. 2011 Jan 1;186(1):25-31 PubMed

Exp Gerontol. 2007 Jun;42(6):463-71 PubMed

J Immunol. 2006 Jun 15;176(12):7745-52 PubMed

Diabetes. 2011 Feb;60(2):517-24 PubMed

Science. 2005 Jan 21;307(5708):426-30 PubMed

Arterioscler Thromb Vasc Biol. 2011 Oct;31(10 ):2322-30 PubMed

FEBS Lett. 2004 Aug 13;572(1-3):189-94 PubMed

Diabetes. 2004 May;53(5):1279-84 PubMed

Cell Mol Biol (Noisy-le-grand). 2001 Jun;47(4):619-35 PubMed

J Clin Invest. 2007 Jan;117(1):175-84 PubMed

J Immunol. 2004 Mar 1;172(5):2731-8 PubMed

Crit Rev Immunol. 1999;19(2):155-72 PubMed

J Immunol. 2001 Jul 15;167(2):995-1003 PubMed

J Mol Med (Berl). 2012 Feb;90(2):175-86 PubMed

Diabetes. 2007 Apr;56(4):901-11 PubMed

Physiol Res. 2010;59(1):79-88 PubMed

Diabetes. 2011 May;60(5):1504-11 PubMed

Nat Med. 2009 Aug;15(8):921-9 PubMed

PLoS One. 2013 Jun 18;8(6):e66515 PubMed

Trends Immunol. 2004 Dec;25(12):677-86 PubMed

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2017-21 PubMed

J Virol. 2002 Sep;76(18):9060-8 PubMed

J Leukoc Biol. 2016 Jun;99(6):1107-19 PubMed

J Obes. 2013;2013:291546 PubMed

Am J Respir Cell Mol Biol. 1999 Mar;20(3):474-80 PubMed

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1481-8 PubMed

Cell Death Dis. 2016 Mar 31;7:e2167 PubMed

Immunol Res. 1999;20(2):147-61 PubMed

Immunol Rev. 2009 May;229(1):152-72 PubMed

Diabetes. 1998 Apr;47(4):515-22 PubMed

J Immunol. 1988 Apr 1;140(7):2121-7 PubMed

Curr Opin Lipidol. 2003 Jun;14(3):281-7 PubMed

Nature. 2007 Jun 28;447(7148):1116-20 PubMed

J Biol Chem. 2010 Feb 26;285(9):6153-60 PubMed

J Biol Chem. 2012 Apr 20;287(17):13561-71 PubMed

Int J Obes (Lond). 2015 May;39(5):762-9 PubMed

Neuroimmunomodulation. 2000;8(2):91-7 PubMed

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1211-3 PubMed

J Transl Med. 2014 Sep 16;12:258 PubMed

Diabetol Metab Syndr. 2012 Sep 19;4(1):42 PubMed

Nat Med. 2011 May;17(5):610-7 PubMed

Eur J Endocrinol. 2003 Aug;149(2):129-35 PubMed

PLoS One. 2014 Apr 15;9(4):e94188 PubMed

J Clin Endocrinol Metab. 2009 Nov;94(11):4619-23 PubMed

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5133-8 PubMed

Eur J Immunol. 2013 Aug;43(8):2089-100 PubMed

Obesity (Silver Spring). 2012 Jul;20(7):1372-8 PubMed

FASEB J. 2009 Mar;23(3):866-74 PubMed

J Clin Invest. 1995 May;95(5):2409-15 PubMed

Endocrinol Metab Clin North Am. 2008 Sep;37(3):753-68, x-xi PubMed

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