Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
PubMed
28150341
DOI
10.1111/myc.12595
Knihovny.cz E-zdroje
- Klíčová slova
- Geotrichum, Saprochaete, invasive fungal diseases,
- MeSH
- amfotericin B farmakologie terapeutické užití MeSH
- antifungální látky farmakologie terapeutické užití MeSH
- dospělí MeSH
- echinokandiny farmakologie terapeutické užití MeSH
- flukonazol farmakologie terapeutické užití MeSH
- fungemie diagnóza farmakoterapie mikrobiologie MeSH
- geotrichóza farmakoterapie mikrobiologie mortalita MeSH
- Geotrichum klasifikace účinky léků genetika izolace a purifikace MeSH
- hostitel s imunodeficiencí MeSH
- invazivní mykotické infekce farmakoterapie mikrobiologie mortalita MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipopeptidy farmakologie terapeutické užití MeSH
- micafungin MeSH
- mikrobiální testy citlivosti MeSH
- mladiství MeSH
- mladý dospělý MeSH
- neutropenie komplikace farmakoterapie mikrobiologie MeSH
- registrace * MeSH
- Saccharomycetales klasifikace účinky léků genetika izolace a purifikace MeSH
- senioři MeSH
- vorikonazol farmakologie terapeutické užití MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- amfotericin B MeSH
- antifungální látky MeSH
- echinokandiny MeSH
- flukonazol MeSH
- lipopeptidy MeSH
- micafungin MeSH
- vorikonazol MeSH
Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope™ registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12-year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co-morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were S. capitata (n=14), S. clavata (n=5), G. candidum (n=2) and Geotrichum spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All S. capitata and S. clavata isolates with the exception of one S. capitata (MIC 4 mg/L) isolate had MICs>32 mg/L for caspofungin. For micafungin and anidulafungin, MICs varied between 0.25 and >32 mg/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B ± flucytosine, voriconazole, fluconazole and itraconazole) (P=.036). Echinocandins are not an option for these infections.
1st Department of Internal Medicine Division of Hematology Semmelweis University Budapest Hungary
CBS KNAW Fungal Biodiversity Centre Utrecht Netherlands
Clinical Trials Centre Cologne ZKS Köln Cologne Germany
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases Cologne Germany
Department of Microbiology Sri Ramachandra Medical College and Research Institute Chennai India
German Centre for Infection Research Partner Site Bonn Cologne Cologne Germany
Institute for Virology and Medical Microbiology University Witten Herdecke Witten Germany
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