Cervical fluid calreticulin and cathepsin-G in pregnancies complicated by preterm prelabor rupture of membranes
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Preterm delivery, amniotic fluid, marker, non-invasive sample,
- MeSH
- biologické markery analýza MeSH
- chorioamnionitida diagnóza mikrobiologie MeSH
- dospělí MeSH
- ELISA MeSH
- gestační stáří MeSH
- interleukin-6 analýza MeSH
- kalretikulin analýza MeSH
- kathepsin G analýza MeSH
- lidé MeSH
- mladý dospělý MeSH
- plodová voda chemie metabolismus mikrobiologie MeSH
- předčasný odtok plodové vody metabolismus mikrobiologie MeSH
- prospektivní studie MeSH
- senzitivita a specificita MeSH
- těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- CALR protein, human MeSH Prohlížeč
- CTSG protein, human MeSH Prohlížeč
- interleukin-6 MeSH
- kalretikulin MeSH
- kathepsin G MeSH
OBJECTIVE: The study aimed to determine the cervical calreticulin and cathepsin-G concentrations in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) with respect to the presence of microbial invasion of the amniotic cavity (MIAC) and intra-amniotic inflammation (IAI). METHODS: Eighty women with singleton pregnancies complicated by PPROM were included in this study. Cervical and amniotic fluids were obtained at the time of admission, and concentrations of calreticulin and cathepsin-G in cervical fluid were determined using ELISA. The MIAC was defined as a positive PCR analysis for Ureaplasma species, Mycoplasma hominis, and/or Chlamydia trachomatis and/or by positivity for the 16S rRNA gene. IAI was defined as amniotic fluid bedside IL-6 concentrations ≥745 pg/mL Result: Neither women with MIAC nor with IAI had different cervical fluid concentrations of calreticulin (with MIAC: median 18.9 pg/mL vs. without MIAC: median 14.7 pg/mL, p = 0.28; with IAI: median 14.3 pg/mL vs. without IAI: median 15.6 pg/mL, p = 0.57;) or of cathepsin-G (with MIAC: median 30.7 pg/mL vs. without MIAC: median 24.7 pg/mL, p = 0.28; with IAI: median 27.3 pg/mL vs. without IAI: median 25.1 pg/mL, p = 0.80) than women without those complications. No associations between amniotic fluid IL-6 concentrations, gestational age at sampling, and cervical fluid calreticulin and cathepsin-G concentrations were found. CONCLUSIONS: Cervical fluid calreticulin and cathepsin-G concentrations did not reflect the presence of MIAC or IAI in women with PPROM.
Department of Obstetrics and Gynecology Sahlgrenska Academy Gothenburg University Gothenburg Sweden
f Department of Medical Genetics Peking University Health Science Center Peking China
g Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
Citace poskytuje Crossref.org
