The Heidenhain variant of Creutzfeldt-Jakob disease and concomitant tau pathology: A case report
Jazyk angličtina Země Polsko Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
PubMed
28236445
DOI
10.1016/j.pjnns.2017.01.011
PII: S0028-3843(16)30115-3
Knihovny.cz E-zdroje
- Klíčová slova
- Creutzfeldt–Jakob disease, Heidenhain variant, Prion, Visuospatial dysfunction,
- MeSH
- Creutzfeldtova-Jakobova nemoc diagnóza patologie MeSH
- diferenciální diagnóza MeSH
- difuzní magnetická rezonance MeSH
- elektroencefalografie MeSH
- fatální výsledek MeSH
- fosforylace MeSH
- komorbidita MeSH
- lidé MeSH
- mozek patologie MeSH
- neurologické vyšetření MeSH
- poruchy zraku diagnóza patologie MeSH
- proteiny 14-3-3 mozkomíšní mok MeSH
- proteiny tau chemická syntéza MeSH
- senioři MeSH
- tauopatie diagnóza patologie MeSH
- týlní lalok patologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- proteiny 14-3-3 MeSH
- proteiny tau MeSH
The Heidenhain form of Creutzfeldt-Jakob disease (CJD) is a rare CJD variant with predominantly visual symptoms in the early stages. Clinical manifestations of metamorphopsia, hemianopia and Balint's syndrome correlate with the involvement of the posterior cortical regions. A 71-year old healthy and very active man was admitted because of impaired visual acuity, hemianopia, and gait disturbance progressing over one week. MRI found typical cortical hyperintensities in the occipital regions while rhythm slowing and sharp waves were seen in the occipital regions on EEG. Protein 14-3-3 was detected in the cerebrospinal fluid. Postmortem neuropathology revealed typical histopathological changes consistent with CJD. Moreover, we found deposits of phosphorylated tau protein in the limbic regions that met the criteria for primary age-related tauopathy (PART); representing an additional and interesting finding in our case.
Citace poskytuje Crossref.org
