Positive and Negative Signals in Mast Cell Activation
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
28254170
DOI
10.1016/j.it.2017.01.008
PII: S1471-4906(17)30022-4
Knihovny.cz E-resources
- MeSH
- Ki-1 Antigen metabolism MeSH
- Cell Degranulation * MeSH
- Immunomodulation MeSH
- Antimicrobial Cationic Peptides metabolism MeSH
- Humans MeSH
- Mast Cells immunology MeSH
- Neuropeptides metabolism MeSH
- Nerve Tissue Proteins metabolism MeSH
- Receptors, IgE metabolism MeSH
- Receptors, Neuropeptide metabolism MeSH
- Receptors, G-Protein-Coupled metabolism MeSH
- Signal Transduction * MeSH
- Ganglia, Spinal metabolism MeSH
- Tetraspanins metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Names of Substances
- Ki-1 Antigen MeSH
- FCER1A protein, human MeSH Browser
- Antimicrobial Cationic Peptides MeSH
- MRGPRX2 protein, human MeSH Browser
- Neuropeptides MeSH
- Nerve Tissue Proteins MeSH
- Receptors, IgE MeSH
- Receptors, Neuropeptide MeSH
- Receptors, G-Protein-Coupled MeSH
- Tetraspanins MeSH
Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds of activation, these cells release a variety of preformed biologically active products, followed by a wave of mediator synthesis and secretion. Increasing evidence suggests that an intricate network of inhibitory and activating receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to stimuli. Here, we discuss the biological and clinical relevance of negative and positive signaling modalities that control mast cell activation, with an emphasis on novel FcεRI regulators, immunoglobulin E (IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins, and the CD300 family of inhibitory and activating receptors.
References provided by Crossref.org
Molecular Mechanisms of Mast Cell Activation by Cholesterol-Dependent Cytolysins
Tetraspanins in the regulation of mast cell function
