The transcriptional repressor HIC1 regulates intestinal immune homeostasis
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
128090
CIHR - Canada
MOP-89773
CIHR - Canada
MOP-106623
CIHR - Canada
PubMed
28327618
DOI
10.1038/mi.2017.17
PII: S1933-0219(22)00751-6
Knihovny.cz E-zdroje
- MeSH
- homeostáza MeSH
- imunita MeSH
- interleukin-17 metabolismus MeSH
- kultivované buňky MeSH
- myši transgenní MeSH
- myši MeSH
- regulace genové exprese MeSH
- represorové proteiny metabolismus MeSH
- sliznice fyziologie MeSH
- střeva fyziologie MeSH
- T-lymfocyty fyziologie MeSH
- transkripční faktory Krüppel-like genetika metabolismus MeSH
- tretinoin metabolismus MeSH
- zánět imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- Hic1 protein, mouse MeSH Prohlížeč
- interleukin-17 MeSH
- represorové proteiny MeSH
- transkripční faktory Krüppel-like MeSH
- tretinoin MeSH
The intestine is a unique immune environment that must respond to infectious organisms but remain tolerant to commensal microbes and food antigens. However, the molecular mechanisms that regulate immune cell function in the intestine remain unclear. Here we identify the POK/ZBTB family transcription factor hypermethylated in cancer 1 (HIC1, ZBTB29) as a central component of immunity and inflammation in the intestine. HIC1 is specifically expressed in immune cells in the intestinal lamina propria (LP) in the steady state and mice with a T-cell-specific deletion of HIC1 have reduced numbers of T cells in the LP. HIC1 expression is regulated by the Vitamin A metabolite retinoic acid, as mice raised on a Vitamin A-deficient diet lack HIC1-positive cells in the intestine. HIC1-deficient T cells overproduce IL-17A in vitro and in vivo, and fail to induce intestinal inflammation, identifying a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions.
Infection and Immunity Program Monash Biomedicine Discovery Institute Clayton Victoria Australia
The Biomedical Research Centre University of British Columbia Vancouver British Columbia Canada
Zobrazit více v PubMed
Immunol Rev. 2012 May;247(1):107-19 PubMed
Nat Immunol. 2008 Oct;9(10):1122-30 PubMed
Curr Protoc Immunol. 2014 Feb 04;104:Unit 15.25. PubMed
Science. 2007 Jul 13;317(5835):256-60 PubMed
Nature. 2014 Apr 17;508(7496):397-401 PubMed
Mucosal Immunol. 2011 Jan;4(1):66-82 PubMed
Nat Immunol. 2007 Dec;8(12):1390-7 PubMed
Cancer Lett. 2016 Jul 1;376(2):387-98 PubMed
J Immunol. 1999 Jun 1;162(11):6641-9 PubMed
Nat Med. 1995 Jun;1(6):570-7 PubMed
Nat Immunol. 2008 Oct;9(10):1113-21 PubMed
Gut. 2002 Aug;51(2):155-63 PubMed
Gut. 2012 Dec;61(12):1693-700 PubMed
Immunity. 2011 Mar 25;34(3):435-47 PubMed
Gastroenterology. 1994 Dec;107(6):1643-52 PubMed
Genesis. 2011 Mar;49(3):142-51 PubMed
Immunity. 2010 Aug 27;33(2):279-88 PubMed
Nucleic Acids Res. 2012 Feb;40(4):1609-20 PubMed
Cell Cycle. 2013 Jul 15;12(14):2266-76 PubMed
Biochem Biophys Res Commun. 2012 May 4;421(2):384-8 PubMed
EMBO J. 2006 Jun 7;25(11):2326-37 PubMed
N Engl J Med. 2012 Mar 29;366(13):1181-9 PubMed
Nat Immunol. 2012 Oct;13(10):991-9 PubMed
Cell. 2010 Mar 19;140(6):845-58 PubMed
J Biol Chem. 2011 Sep 23;286(38):33322-34 PubMed
Cell. 2005 Nov 4;123(3):437-48 PubMed
Nat Immunol. 2011 Mar;12(3):255-63 PubMed
Nature. 2009 Jul 2;460(7251):103-7 PubMed
Eur J Immunol. 2007 Sep;37(9):2396-9 PubMed
N Engl J Med. 2012 Mar 29;366(13):1190-9 PubMed
Nat Immunol. 2013 Dec;14(12):1285-93 PubMed
Trends Immunol. 2011 Sep;32(9):412-9 PubMed
Immunity. 2008 Nov 14;29(5):758-70 PubMed
Nature. 2015 Feb 19;518(7539):417-21 PubMed
Trends Cell Biol. 2006 Nov;16(11):578-87 PubMed
J Allergy Clin Immunol. 2015 Mar;135(3):626-35 PubMed
Nat Rev Immunol. 2011 Jun 17;11(7):445-56 PubMed
Arthritis Rheum. 2010 Apr;62(4):929-39 PubMed
Science. 2009 Aug 21;325(5943):1001-5 PubMed
Immunol Rev. 2014 Jul;260(1):102-17 PubMed
Nat Genet. 2003 Feb;33(2):197-202 PubMed
Semin Immunol. 2007 Apr;19(2):127-35 PubMed
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9394-9 PubMed
Immunity. 2015 Oct 20;43(4):739-50 PubMed
Immunity. 2009 Apr 17;30(4):471-2; author reply 472-3 PubMed
Expert Opin Ther Targets. 2013 Jul;17(7):811-27 PubMed
Immunity. 2008 Sep 19;29(3):391-403 PubMed
Mucosal Immunol. 2011 Jan;4(1):31-42 PubMed
Blood. 1996 Jun 15;87(12):5257-68 PubMed
J Biol Chem. 2012 Mar 23;287(13):10509-24 PubMed
Immunity. 2015 Mar 17;42(3):499-511 PubMed
Immunity. 2004 Oct;21(4):527-38 PubMed
EMBO J. 2007 Apr 4;26(7):1913-23 PubMed
Mol Cell Biol. 2010 Aug;30(16):4045-59 PubMed
Immunity. 2010 May 28;32(5):605-15 PubMed
Immunity. 2015 Oct 20;43(4):727-38 PubMed
Nature. 2004 Jan 22;427(6972):355-60 PubMed
J Exp Med. 2005 Oct 17;202(8):1063-73 PubMed
Nature. 2011 Jul 17;475(7357):514-8 PubMed
Int Immunol. 1993 Nov;5(11):1461-71 PubMed
Immunol Rev. 2012 Sep;249(1):27-42 PubMed
