Karcinóm prištítneho telieska
[Parathyroid cancer]
Language Czech Country Czech Republic Media print
Document type Journal Article
PubMed
28334546
PII: 60536
- MeSH
- Kidney Failure, Chronic epidemiology MeSH
- Hypercalcemia etiology MeSH
- Hyperparathyroidism etiology MeSH
- Hypoxanthine Phosphoribosyltransferase genetics MeSH
- Carcinoma complications epidemiology genetics surgery MeSH
- Neck MeSH
- Humans MeSH
- Mutation MeSH
- Parathyroid Neoplasms complications epidemiology genetics surgery MeSH
- Radiotherapy statistics & numerical data MeSH
- Risk Factors MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Hypoxanthine Phosphoribosyltransferase MeSH
Parathyroid cancer is a rare endocrine malignancy, representing less than 1 % of all cases of primary hyperparathyroidism. The exact etiology of the disease remains unknown. Known risk factors include neck irradiation, end stage renal failure, genetic factors, particularly the the HPRT2/CDCT73 gene mutation. The clinical picture is often indolent, yet progressive with a trend of local invasion and metastasis formation in advanced disease. The clinical picture includes symptoms of severe and resistant hypercalcemia, requiring intensive therapy often with the need of dialysis. Radical surgery is the mainstay of the parathyroid cancer treatment. Chemotherapy and radiotherapy are generally ineffective. An early and correct diagnosis of parathyroid carcinoma significantly influences both morbidity and mortality.Key words: diagnosis - hyperparathyroidism - parathyroid cancer - treatment.