Evidence of necroptosis in hearts subjected to various forms of ischemic insults
Jazyk angličtina Země Kanada Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
28472590
DOI
10.1139/cjpp-2016-0609
Knihovny.cz E-zdroje
- Klíčová slova
- cell death, heart failure, insuffisance cardiaque, ischemic preconditioning, ischémie myocardique, mort des cellules, myocardial ischemia, necroptosis, nécroptose, nécrose passive, passive necrosis, préconditionnement ischémique,
- MeSH
- apoptóza * účinky léků MeSH
- ischemická choroba srdeční metabolismus patologie MeSH
- komplex proteinů jaderného póru metabolismus MeSH
- lidé MeSH
- myokard metabolismus patologie MeSH
- nekróza MeSH
- proteinkinasy metabolismus MeSH
- proteiny vázající RNA metabolismus MeSH
- serin-threoninkinasy interagující s receptory metabolismus MeSH
- signální transdukce MeSH
- TNF-alfa metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- AGFG1 protein, human MeSH Prohlížeč
- komplex proteinů jaderného póru MeSH
- MLKL protein, human MeSH Prohlížeč
- proteinkinasy MeSH
- proteiny vázající RNA MeSH
- RIPK3 protein, human MeSH Prohlížeč
- serin-threoninkinasy interagující s receptory MeSH
- TNF-alfa MeSH
Long-lasting ischemia can result in cell loss; however, repeated episodes of brief ischemia increase the resistance of the heart against deleterious effects of subsequent prolonged ischemic insult and promote cell survival. Traditionally, it is believed that the supply of blood to the ischemic heart is associated with release of cytokines, activation of inflammatory response, and induction of necrotic cell death. In the past few years, this paradigm of passive necrosis as an uncontrolled cell death has been re-examined and the existence of a strictly regulated form of necrotic cell death, necroptosis, has been documented. This controlled cell death modality, resembling all morphological features of necrosis, has been investigated in different types of ischemia-associated heart injuries. The process of necroptosis has been found to be dependent on the activation of RIP1-RIP3-MLKL axis, which induces changes leading to the rupture of cell membrane. This pathway is activated by TNF-α, which has also been implicated in the cardioprotective signaling pathway of ischemic preconditioning. Thus, this review is intended to describe the TNF-α-mediated signaling leading to either cell survival or necroptotic cell death. In addition, some experimental data suggesting a link between heart dysfunction and the cellular loss due to necroptosis are discussed in various conditions of myocardial ischemia.
Citace poskytuje Crossref.org
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