Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
28477868
DOI
10.1016/j.cis.2017.04.006
PII: S0001-8686(17)30091-X
Knihovny.cz E-zdroje
- Klíčová slova
- BioSAXS, Drug delivery, Liquid crystalline nanocarriers, Nanomedicines, Nanostructured lipid carriers, Self-assembled biomaterials,
- MeSH
- difrakce rentgenového záření MeSH
- fytonutrienty chemie farmakologie MeSH
- hydrofobní a hydrofilní interakce MeSH
- koloidy MeSH
- lidé MeSH
- malá interferující RNA genetika metabolismus MeSH
- maloúhlový rozptyl MeSH
- nanočástice chemie MeSH
- nosiče léků * MeSH
- peptidy chemie metabolismus MeSH
- plazmidy chemie metabolismus MeSH
- příprava léků metody MeSH
- protinádorové látky chemie farmakologie MeSH
- uvolňování léčiv MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- fytonutrienty MeSH
- koloidy MeSH
- malá interferující RNA MeSH
- nosiče léků * MeSH
- peptidy MeSH
- protinádorové látky MeSH
The present work highlights recent achievements in development of nanostructured dispersions and biocolloids for drug delivery applications. We emphasize the key role of biological small-angle X-ray scattering (BioSAXS) investigations for the nanomedicine design. A focus is given on controlled encapsulation of small molecular weight phytochemical drugs in lipid-based nanocarriers as well as on encapsulation of macromolecular siRNA, plasmid DNA, peptide and protein pharmaceuticals in nanostructured nanoparticles that may provide efficient intracellular delivery and triggered drug release. Selected examples of utilisation of the BioSAXS method for characterization of various types of liquid crystalline nanoorganizations (liposome, spongosome, cubosome, hexosome, and nanostructured lipid carriers) are discussed in view of the successful encapsulation and protection of phytochemicals and therapeutic biomolecules in the hydrophobic or the hydrophilic compartments of the nanocarriers. We conclude that the structural design of the nanoparticulate carriers is of crucial importance for the therapeutic outcome and the triggered drug release from biocolloids.
Citace poskytuje Crossref.org
Lipid-based liquid crystalline materials in electrochemical sensing and nanocarrier technology
