Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review
PubMed
28477868
DOI
10.1016/j.cis.2017.04.006
PII: S0001-8686(17)30091-X
Knihovny.cz E-resources
- Keywords
- BioSAXS, Drug delivery, Liquid crystalline nanocarriers, Nanomedicines, Nanostructured lipid carriers, Self-assembled biomaterials,
- MeSH
- X-Ray Diffraction MeSH
- Phytochemicals chemistry pharmacology MeSH
- Hydrophobic and Hydrophilic Interactions MeSH
- Colloids MeSH
- Humans MeSH
- RNA, Small Interfering genetics metabolism MeSH
- Scattering, Small Angle MeSH
- Nanoparticles chemistry MeSH
- Drug Carriers * MeSH
- Peptides chemistry metabolism MeSH
- Plasmids chemistry metabolism MeSH
- Drug Compounding methods MeSH
- Antineoplastic Agents chemistry pharmacology MeSH
- Drug Liberation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Phytochemicals MeSH
- Colloids MeSH
- RNA, Small Interfering MeSH
- Drug Carriers * MeSH
- Peptides MeSH
- Antineoplastic Agents MeSH
The present work highlights recent achievements in development of nanostructured dispersions and biocolloids for drug delivery applications. We emphasize the key role of biological small-angle X-ray scattering (BioSAXS) investigations for the nanomedicine design. A focus is given on controlled encapsulation of small molecular weight phytochemical drugs in lipid-based nanocarriers as well as on encapsulation of macromolecular siRNA, plasmid DNA, peptide and protein pharmaceuticals in nanostructured nanoparticles that may provide efficient intracellular delivery and triggered drug release. Selected examples of utilisation of the BioSAXS method for characterization of various types of liquid crystalline nanoorganizations (liposome, spongosome, cubosome, hexosome, and nanostructured lipid carriers) are discussed in view of the successful encapsulation and protection of phytochemicals and therapeutic biomolecules in the hydrophobic or the hydrophilic compartments of the nanocarriers. We conclude that the structural design of the nanoparticulate carriers is of crucial importance for the therapeutic outcome and the triggered drug release from biocolloids.
References provided by Crossref.org
Lipid-based liquid crystalline materials in electrochemical sensing and nanocarrier technology
