Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries; however, there are no data regarding clinical phenotypes of these patients in this region.Participation in the Phenotypes of COPD in Central and Eastern Europe (POPE) study was offered to stable patients with COPD in a real-life setting. The primary aim of this study was to assess the prevalence of phenotypes according to predefined criteria. Secondary aims included analysis of differences in symptom load, comorbidities and pharmacological treatment.3362 patients with COPD were recruited in 10 CEE countries. 63% of the population were nonexacerbators, 20.4% frequent exacerbators with chronic bronchitis, 9.5% frequent exacerbators without chronic bronchitis and 6.9% were classified as asthma-COPD overlap. Differences in the distribution of phenotypes between countries were observed, with the highest heterogeneity observed in the nonexacerbator cohort and the lowest heterogeneity observed in the asthma-COPD cohort. There were statistically significant differences in symptom load, lung function, comorbidities and treatment between these phenotypes.The majority of patients with stable COPD in CEE are nonexacerbators; however, there are distinct differences in surrogates of disease severity and therapy between predefined COPD phenotypes.

Clinic for Pulmonary Diseases Faculty of Medicine Clinical Centre of Serbia Belgrade Serbia

Clinic of Pulmonary Diseases Military Medical Academy Sofia Bulgaria

Dept of Pneumology School of Medicine in Katowice Medical University of Silesia Katowice Poland

Dept of Pneumology University Hospital Hradec Kralove Faculty of Medicine in Hradec Kralove Charles University Prague Hradec Kralove Czech Republic

Dept of Pulmonology University of Szeged Deszk Hungary

Dept of Respiratory and Critical Care Medicine Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology Otto Wagner Spital Vienna Austria

Dept of Respiratory Medicine and Tuberculosis Faculty of Medicine P J Safarik University Kosice Slovakia

Faculty of Medicine University of Latvia Riga Latvia

Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Brno Czech Republic

Laboratory of Pulmonology Moscow State University of Medicine and Dentistry named after A 1 Evdokimov Moscow Russia

Pneumology Dept Hospital Universitari Vall d'Hebron CIBER de Enfermedades Respiratorias Barcelona Spain

Pulmonary Dept Topolsica Hospital Topolsica Slovenia

School of Medicine Zagreb University Hospital Dubrava Zagreb Croatia

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Eur Respir J. 2017 May 11;49(5):1700054. doi: 10.1183/13993003.00054-2017. PubMed

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