Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Review
PubMed
28632451
DOI
10.4155/fmc-2017-0030
Knihovny.cz E-resources
- Keywords
- antineoplastic effect, cognition-enhancer, naturally occurring POP inhibitors, neuropsychiatric disorders, prolyl oligopeptidase, prolyl oligopeptidase inhibitors, synthetic POP inhibitors,
- MeSH
- Serine Proteinase Inhibitors chemistry pharmacology MeSH
- Humans MeSH
- Models, Molecular MeSH
- Molecular Structure MeSH
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases metabolism MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Serine Proteinase Inhibitors MeSH
- PREPL protein, human MeSH Browser
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases MeSH
Prolyl oligopeptidase (POP), also called prolyl endopeptidase, is a cytosolic enzyme investigated by several research groups. It has been proposed to play an important role in physiological processes such as modulation of the levels of several neuronal peptides and hormones containing a proline residue. Due to its proteolytic activity and physiological role in cell signaling pathways, inhibition of POP offers an emerging approach for the treatment of Alzheimer's and Parkinson's diseases as well as other diseases related to cognitive impairment. Furthermore, it may also represent an interesting target for treatment of neuropsychiatric disorders, and as an antiangiogenesis or antineoplastic agent. In this review paper, we summarized naturally occurring POP inhibitors together with peptide-like inhibitors and their biological effects. Some of them have shown promising results and interesting pharmacological profiles. However, to date, there is no POP inhibitor available on the market although several clinical trials have been undertaken.
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