Core-shell PLA-PVA porous microparticles as carriers for bacteriocin nisin
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
- Keywords
- Microparticles, antibacterial activity, core–shell, nisin, poly(vinyl alcohol), polylactic acid,
- MeSH
- Anti-Bacterial Agents administration & dosage MeSH
- Glutarates chemistry MeSH
- Listeria monocytogenes drug effects MeSH
- Microscopy, Electron, Scanning MeSH
- Nisin administration & dosage MeSH
- Drug Carriers chemistry MeSH
- Polyesters chemistry MeSH
- Polyvinyl Alcohol chemistry MeSH
- Porosity MeSH
- Particle Size MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Glutarates MeSH
- glutaric acid MeSH Browser
- Nisin MeSH
- Drug Carriers MeSH
- poly(lactide) MeSH Browser
- Polyesters MeSH
- Polyvinyl Alcohol MeSH
This work is focused on preparation of novel porous type of core-shell-structured microparticles based on polylactide (shell) and poly(vinyl alcohol) cross-linked with glutaric acid (GA) (core) prepared by water-in-oil-in-water solvent evaporation technique. The microparticle systems were used as delivery systems for immobilisation of model antibacterial agent - nisin. The effect of cross-linking and the initial amount of nisin on their morphology was investigated using scanning electron microscopy, BET analysis, zeta potential measurement and Fourier transform infra-red spectroscopy. Encapsulation efficiency and release profile of nisin from the microparticles were studied by high performance liquid chromatography. Antibacterial activity of the prepared systems was tested by dilution and spread plate technique. Results showed the microparticles in the size range of 9-16 μm in diameter with spherical multi-hollow core-shell structure. The presence of cross-linking agent GA influences the release profile of the peptide and has synergistic effect on Listeria monocytogenes growth reduction.
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