Adherence with perindopril therapy: a pilot study using therapeutic drug monitoring of perindoprilat and an evaluation of the clearance estimation
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu klinické zkoušky, časopisecké články
Grantová podpora
Progres Q25
Univerzita Karlova v Praze
SVV 260373
Univerzita Karlova v Praze
PubMed
28791494
DOI
10.1007/s11096-017-0522-7
PII: 10.1007/s11096-017-0522-7
Knihovny.cz E-zdroje
- Klíčová slova
- ACE inhibitors, Compliance, Creatinine, Cystatin C, Perindopril, Therapeutic drug monitoring,
- MeSH
- adherence k farmakoterapii * MeSH
- cystatin C metabolismus MeSH
- hodnoty glomerulární filtrace účinky léků fyziologie MeSH
- inhibitory ACE metabolismus farmakologie MeSH
- kreatinin metabolismus MeSH
- lidé MeSH
- metabolická clearance účinky léků fyziologie MeSH
- monitorování léčiv metody MeSH
- perindopril metabolismus farmakologie MeSH
- pilotní projekty MeSH
- prospektivní studie MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- Názvy látek
- cystatin C MeSH
- inhibitory ACE MeSH
- kreatinin MeSH
- perindopril MeSH
Background Although measurement of drug serum levels is an objective direct method for testing compliance, it can be distorted by "white-coat compliance" or by variations in drug elimination. Objective The aim of this prospective study was to evaluate the prevalence of noncompliance with perindopril therapy in adult out-patients using pharmacokinetic simulations. The additional aim was to compare the predictive performance of two glomerular filtration rate markers-creatinine and cystatin C. Setting Department of Cardiology, Tomas Bata Regional Hospital in Zlín, Czech Republic. Method Perindoprilat pharmacokinetic models individualized according to patient characteristics were compared with measured perindoprilat serum concentrations to document compliance. Linear regression was used to evaluate the relations between perindoprilat clearance and glomerular filtration rate estimated using creatinine and cystatin C. Main outcome measure Assessment of non-compliance with medication using drug concentration measurements reinforced with therapeutic drug monitoring. Results Non-detectable perindoprilat levels were observed in 26.1% of patients. Another 21.7% were classified as non-compliant based on therapeutic drug monitoring pharmacokinetic simulations. Volume of distribution, clearance and half-life median value (interquarti°range) for perindoprilat were 408.3 (360.4-456.8) L, 10.1 (4.9-17.0) L h-1 and 24.7 (19.4-62.7) h, respectively. Linear regression models showed tight relationship between cystatin C and perindoprilat clearance. Conclusions Assessment of adherence with medication reinforced with therapeutic drug monitoring and pharmacokinetic simulations is proposed as an optimal method reducing disadvantages of simple drug concentration measurements. Cystatin C proves to be better surrogate marker for perindoprilat elimination than creatinine.
Zobrazit více v PubMed
Clin Chem. 2015 Oct;61(10):1265-72 PubMed
Clin Chem. 2002 May;48(5):699-707 PubMed
Hypertens Res. 2011 Jan;34(1):87-90 PubMed
Br J Clin Pharmacol. 2015 Jul;80(1):20-7 PubMed
N Engl J Med. 2012 Jul 5;367(1):20-9 PubMed
Br J Clin Pharmacol. 1998 Aug;46(2):95-9 PubMed
N Engl J Med. 2005 Aug 4;353(5):487-97 PubMed
Medicine (Baltimore). 2017 Jan;96(4):e5641 PubMed
Ther Adv Chronic Dis. 2012 Sep;3(5):231-6 PubMed
J Hypertens. 2013 Dec;31(12):2455-61 PubMed
Nephrol Dial Transplant. 2003 Oct;18(10):2024-31 PubMed
Br J Clin Pharmacol. 1991 Aug;32(2):187-92 PubMed
Intern Med J. 2016 Mar;46(3):364-72 PubMed
