JavaScript is NOT enabled !

Please enable JavaScript.

Article

PubMed

This record comes from PubMed

Age-Related Differences in Non-Persistence with Statin Treatment in Patients after a Transient Ischaemic Attack

Wawruch, Martin
Author Wawruch, Martin ORCID Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovakia. martin.wawruch@gmail.com
Zatko, Dusan
Author Zatko, Dusan General Health Insurance Company, Panónska cesta 2, 851 04, Bratislava, Slovakia
Wimmer, Gejza Jr
Author Wimmer, Gejza Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovakia
Luha, Jan
Author Luha, Jan Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovakia
Wimmerova, Sona
Author Wimmerova, Sona Department of Biophysics, Informatics and Biostatistics, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03, Bratislava, Slovakia
Matalova, Petra
Author Matalova, Petra Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15, Olomouc, Czech Republic
Kukumberg, Peter
Author Kukumberg, Peter 2nd Department of Neurology, Faculty of Medicine, Comenius University, Limbová 5, 833 05, Bratislava, Slovakia
Murin, Jan
Author Murin, Jan 1st Department of Internal Medicine, Faculty of Medicine, Comenius University, Mickiewiczova 13, 813 69, Bratislava, Slovakia
Tesar, Tomas
Author Tesar, Tomas Department of Organisation and Management of Pharmacy, Faculty of Pharmacy, Comenius University, Kalinciakova 8, 832 32, Bratislava, Slovakia
Havelkova, Beata
Author Havelkova, Beata General Health Insurance Company, Panónska cesta 2, 851 04, Bratislava, Slovakia
Shah, Rashmi
Author Shah, Rashmi Independent Pharmaceutical Consultant, 8 Birchdale, Gerrards Cross, Buckinghamshire, SL9 7JA, UK

Clinical drug investigation. 2017 Nov ; 37 (11) : 1047-1054.

Clin Drug Investig
ISSN 1179-1918 | 1173-2563
Source

Language English Country New Zealand Media print

Document type Journal Article

Persistent link https://www.medvik.cz/link/pmid28791591

PubMed 28791591
DOI 10.1007/s40261-017-0559-3
PII: 10.1007/s40261-017-0559-3
Knihovny.cz E-resources

MeSH
Medication Adherence * MeSH
Diabetes Mellitus epidemiology MeSH
Hypercholesterolemia drug therapy MeSH
Cohort Studies MeSH
Middle Aged MeSH
Humans MeSH
Polypharmacy MeSH
Proportional Hazards Models MeSH
Aged, 80 and over MeSH
Aged MeSH
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use MeSH
Ischemic Attack, Transient drug therapy MeSH
Check Tag
Middle Aged MeSH
Humans MeSH
Male MeSH
Aged, 80 and over MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Names of Substances
Hydroxymethylglutaryl-CoA Reductase Inhibitors MeSH

BACKGROUND AND OBJECTIVE: Non-persistence with secondary preventive measures, including medications such as statins, adversely affects the prospects of successful outcomes. This study was aimed at evaluating non-persistence with statin therapy in cohorts of young and elderly patients after a transient ischaemic attack (TIA) and identifying patient-associated characteristics that influence the risk for non-persistence. METHODS: The study cohorts included 797 adult patients who were initiated on statin therapy following a TIA diagnosis between 1 January 2010 and 31 December 2010. Patients were followed up for 3 years and those with a treatment gap of at least a 6-month period were considered 'non-persistent'. In order to identify any age-related differences, all analyses were conducted in the entire study cohort (n = 797) as well as separately in the 'younger' (aged <65 years, n = 267) and the 'older' (aged ≥65 years, n = 530) patients. RESULTS: Non-persistence was significantly more common in younger patients compared to older patients (67.8% vs. 49.1%; p < 0.001). Factors that decreased the probability of non-persistence in younger and older patients included diabetes mellitus (hazard ratio [HR] = 0.72 and HR = 0.64, respectively) and hypercholesterolaemia (HR = 0.43 and HR = 0.62, respectively). Female gender (HR = 1.42) was associated with a higher and increasing number of medications taken (HR = 0.93), with lower probability for non-persistence in younger patients but not in the older patients. CONCLUSIONS: Our results indicate that certain patients with TIA require special counselling to improve persistence with statin therapy. These include younger patients, especially females and those not on polypharmacy, and both younger and older patients without diabetes mellitus or hypercholesterolaemia.

1st Department of Internal Medicine Faculty of Medicine Comenius University Mickiewiczova 13 813 69 Bratislava Slovakia

2nd Department of Neurology Faculty of Medicine Comenius University Limbová 5 833 05 Bratislava Slovakia

Department of Biophysics Informatics and Biostatistics Faculty of Public Health Slovak Medical University Limbová 12 833 03 Bratislava Slovakia

Department of Organisation and Management of Pharmacy Faculty of Pharmacy Comenius University Kalinciakova 8 832 32 Bratislava Slovakia

Department of Pharmacology Faculty of Medicine and Dentistry Palacky University Hnevotinska 3 775 15 Olomouc Czech Republic

General Health Insurance Company Panónska cesta 2 851 04 Bratislava Slovakia

Independent Pharmaceutical Consultant 8 Birchdale Gerrards Cross Buckinghamshire SL9 7JA UK

Institute of Medical Biology Genetics and Clinical Genetics Faculty of Medicine Comenius University Sasinkova 4 811 08 Bratislava Slovakia

Institute of Pharmacology and Clinical Pharmacology Faculty of Medicine Comenius University Sasinkova 4 811 08 Bratislava Slovakia

See more in PubMed

N Engl J Med. 2006 Aug 10;355(6):549-59 PubMed

Circ J. 2016;80(3):731-7 PubMed