The common lavender (Lavandula angustifolia Mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer's patch cells
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28821152
DOI
10.1016/j.carbpol.2017.07.011
PII: S0144-8617(17)30777-4
Knihovny.cz E-zdroje
- Klíčová slova
- Immunomodulation, Lavender, Macrophages, Neutrophils, Pectin, Peyer’s patches,
- MeSH
- antiflogistika chemie MeSH
- králíci MeSH
- květy chemie MeSH
- levandule chemie MeSH
- lidé MeSH
- makrofágy účinky léků MeSH
- myši inbrední C3H MeSH
- myši MeSH
- ovce MeSH
- oxid dusnatý metabolismus MeSH
- pektiny farmakologie MeSH
- Peyerovy pláty cytologie MeSH
- polysacharidy MeSH
- RAW 264.7 buňky MeSH
- reaktivní formy kyslíku metabolismus MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiflogistika MeSH
- oxid dusnatý MeSH
- pektiny MeSH
- polysacharidy MeSH
- reaktivní formy kyslíku MeSH
Two pectic (chPS-L1, chPS-L2) and one polyphenolic (chPP-L) fractions were obtained from lavender flowers after boiling water extraction, exhaustive removing of alcohol-soluble molecules and SEC. chPS-L1 (52.4kDa) contains mainly low-acetylated and high-methoxylated homogalacturonans (HG), and smaller rhamnogalacturonan (RG) I backbone fragments rich in 1,3,5-branched arabinan and arabinogalactan (AG) II side chains. chPS-L2 (21.8kDa) contains predominantly similarly esterified HG, followed by RGI with AGII structures and RGII. The prevalence of catechin and epicatechin in chPP-L indicates that they form weak interactions with pectins. chPS-L1 and chPS-L2 enhanced ß2-integrin expression on neutrophils, inducing ROS generation and macrophage NO production. Both the effects on ß2-integrin and high complement fixation activity of chPS-L1 were proposed for its inhibitory action against PMA- and OZP-activated ROS formation. This, together with suppression of NO generation after co-stimulation with chPS-L1 and LPS, suggested anti-inflammatory activity of studied pectins. Lavender polysaccharides expressed intestinal Peyer's patch immunomodulating activity.
Department of Biotechnology University of Food Technologies 26 Maritza Blvd BG 4002 Plovdiv Bulgaria
Department of Chemistry University of Oslo P O Box 1033 Blindern NO 0315 Oslo Norway
Citace poskytuje Crossref.org
