Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
28837783
DOI
10.1016/j.steroids.2017.08.010
PII: S0039-128X(17)30142-3
Knihovny.cz E-zdroje
- Klíčová slova
- BRI1 receptor kinase, Brassinosteroids, Cross-metathesis, Molecular docking, Organic synthesis, Plant bioassays,
- MeSH
- alkeny chemie MeSH
- Arabidopsis účinky léků enzymologie růst a vývoj MeSH
- brassinosteroidy chemická syntéza chemie metabolismus farmakologie MeSH
- hrách setý účinky léků růst a vývoj MeSH
- katalytická doména MeSH
- proteinkinasy chemie metabolismus MeSH
- proteiny huseníčku chemie metabolismus MeSH
- simulace molekulového dockingu MeSH
- techniky syntetické chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- alkeny MeSH
- brassinosteroidy MeSH
- BRI1 protein, Arabidopsis MeSH Prohlížeč
- proteinkinasy MeSH
- proteiny huseníčku MeSH
A series of phenyl analogues of brassinosteroids was prepared via alkene cross-metathesis using commercially available styrenes and 24-nor-5α-chola-2,22-dien-6-one. All derivatives were successfully docked into the active site of BRI1 using AutoDock Vina. Plant growth promoting activity was measured using the pea inhibition biotest and Arabidopsis root sensitivity assay and then was compared with naturally occuring brassinosteroids. Differences in the production of plant hormone ethylene were also observed in etiolated pea seedlings after treatment with the new and also five known brassinosteroid phenyl analogues. Antiproliferative activity was also studied using normal human fibroblast and human cancer cell lines.
Citace poskytuje Crossref.org
Synthesis and Biological Activity of Brassinosteroid Analogues with a Nitrogen-Containing Side Chain
