Experimental methods for flow and aerosol measurements in human airways and their replicas
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review
PubMed
28842353
DOI
10.1016/j.ejps.2017.08.021
PII: S0928-0987(17)30465-7
Knihovny.cz E-resources
- Keywords
- Aerosol deposition, CFD validation, Computational fluid particle dynamics, Experimental methods, Flow measurement techniques, Gas–liquid two-phase flow, Human airways, Lungs, Medical imaging, Velocimetry techniques,
- MeSH
- Respiratory Tract Absorption MeSH
- Aerosols chemistry MeSH
- Administration, Inhalation MeSH
- Models, Biological MeSH
- Chemistry, Pharmaceutical methods MeSH
- Hydrodynamics MeSH
- Laryngeal Masks * MeSH
- Drug Delivery Systems methods MeSH
- Humans MeSH
- Nebulizers and Vaporizers MeSH
- Permeability MeSH
- Lung drug effects MeSH
- Computer Simulation * MeSH
- Powders chemistry MeSH
- Particle Size MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Aerosols MeSH
- Powders MeSH
Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant differences among distinct methods of calculation emphasize the need for highly precise experimental data in order to specify boundary conditions and for validation purposes. This paper reviews and critically evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways. Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational calculations that can be validated are indicated. The review classifies the methods into following categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods are described, applications in human airways studies are illustrated, and recommendations for the most useful applications of each method are given.
Ciber de Enfermedades Respiratorias Av Monforte de Lemos 3 5 Pabellón 11 Planta 0 28029 Madrid Spain
Respiratory Division University Hospital UZ Brussel Vrije Universiteit Brussel Belgium
Universidad Complutense de Madrid Av Monforte de Lemos 3 5 Pabellón 11 Planta 0 28029 Madrid Spain
References provided by Crossref.org
