H+ translocation by weak acid uncouplers is independent of H+ electrochemical gradient

. 2017 Oct ; 49 (5) : 391-397. [epub] 20170912

Jazyk angličtina Země Spojené státy americké Médium print-electronic

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid28900787
Odkazy

PubMed 28900787
DOI 10.1007/s10863-017-9724-x
PII: 10.1007/s10863-017-9724-x
Knihovny.cz E-zdroje

According to the common view, weak acid uncouplers increase proton conductance of biological (and phospholipid bilayer) membranes, thus effecting H+ fluxes driven by their electrochemical gradients. Under certain conditions, however, uncouplers can induce unexpected effects opposite to the dissipation of H+ gradients. Results are presented here demonstrating CCCP-induced proton influx into Saccharomyces cerevisiae cytosol driven by the electrochemical potentials of CCCP and its CCCP- anions, independent of electrochemical H+-gradient. Another view of week acid uncouplers' action is proposed that is logically consistent with these observations.

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