The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28942047
DOI
10.1016/j.exppara.2017.09.022
PII: S0014-4894(17)30308-9
Knihovny.cz E-zdroje
- Klíčová slova
- Albendazole, BALB/C, Encephalitozoon cuniculi genotypes II and III, Microsporidiosis, SCID,
- MeSH
- albendazol farmakologie terapeutické užití MeSH
- antifungální látky farmakologie terapeutické užití MeSH
- Encephalitozoon cuniculi účinky léků genetika imunologie fyziologie MeSH
- encephalitozoonóza farmakoterapie imunologie parazitologie MeSH
- feces parazitologie MeSH
- genotyp MeSH
- imunokompetence * MeSH
- imunokompromitovaný pacient * MeSH
- myši inbrední BALB C MeSH
- myši SCID MeSH
- myši MeSH
- spory hub MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- albendazol MeSH
- antifungální látky MeSH
Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host. The experimental treatment with albendazole of immunocompetent BALB/c mice infected with E. cuniculi III have shown very weak effect. Our findings clearly showed that the different course of infection and response to treatment depends not only on the immunological status of the host, but also on the genotype of microsporidia. It could be very important especially for individuals under chemotherapy and transplant recipients of organs originating from infected donors.
Citace poskytuje Crossref.org
Chronic Infections in Mammals Due to Microsporidia
Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci
