A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial
Language English Country Germany Media print-electronic
Document type Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial
PubMed
28944412
DOI
10.1007/s00384-017-2901-x
PII: 10.1007/s00384-017-2901-x
Knihovny.cz E-resources
- Keywords
- Ascorbic acid, Colonoscopy, Magnesium citrate, Picosulfate sodium, Polyethylene glycol,
- MeSH
- Citrates administration & dosage adverse effects MeSH
- Colonoscopy * MeSH
- Ascorbic Acid administration & dosage adverse effects MeSH
- Citric Acid administration & dosage adverse effects MeSH
- Therapeutic Irrigation adverse effects methods MeSH
- Humans MeSH
- Organometallic Compounds administration & dosage adverse effects MeSH
- Picolines administration & dosage adverse effects MeSH
- Polyethylene Glycols administration & dosage adverse effects MeSH
- Laxatives administration & dosage adverse effects MeSH
- Prospective Studies MeSH
- Cathartics administration & dosage adverse effects MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Randomized Controlled Trial MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Citrates MeSH
- Ascorbic Acid MeSH
- Citric Acid MeSH
- magnesium citrate MeSH Browser
- MoviPrep MeSH Browser
- Organometallic Compounds MeSH
- picosulfate sodium MeSH Browser
- Picolines MeSH
- Polyethylene Glycols MeSH
- Laxatives MeSH
- Cathartics MeSH
PURPOSE: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. METHODS: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. RESULTS: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). CONCLUSIONS: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.
2nd Department of Internal Medicine 3rd Faculty of Medicine Charles University Prague Czech Republic
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