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Clausena anisata and Dysphania ambrosioides essential oils: from ethno-medicine to modern uses as effective insecticides

Pavela, Roman
Author Pavela, Roman Crop Research Institute, Drnovska 507, 161 06, Prague 6, Czech Republic
Maggi, Filippo
Author Maggi, Filippo School of Pharmacy, University of Camerino, Camerino, Italy
Lupidi, Giulio
Author Lupidi, Giulio School of Pharmacy, University of Camerino, Camerino, Italy
Mbuntcha, Hélène
Author Mbuntcha, Hélène Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, Dschang, Cameroon
Woguem, Verlaine
Author Woguem, Verlaine Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, Dschang, Cameroon
Womeni, Hilaire Macaire
Author Womeni, Hilaire Macaire Laboratory of Biochemistry of Medicinal Plants, Food Science and Nutrition, Faculty of Science, University of Dschang, Dschang, Cameroon
Barboni, Luciano
Author Barboni, Luciano School of Science and Technology, University of Camerino, Camerino, Italy
Tapondjou, Léon Azefack
Author Tapondjou, Léon Azefack Laboratory of Environmental and Applied Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
Benelli, Giovanni
Author Benelli, Giovanni Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy. benelli.giovanni@gmail.com

Environmental science and pollution research international. 2018 Apr ; 25 (11) : 10493-10503. [epub] 20171001

Environ Sci Pollut Res Int
ISSN 1614-7499 | 0944-1344
Source

Language English Country Germany Media print-electronic

Document type Journal Article

Persistent link https://www.medvik.cz/link/pmid28965298

PubMed 28965298
DOI 10.1007/s11356-017-0267-9
PII: 10.1007/s11356-017-0267-9
Knihovny.cz E-resources

Keywords
Clausena anisata, Culex quinquefasciatus, Dysphania ambrosioides, Ethno-botanical pesticides, Musca domestica, St. Louis encephalitis,
MeSH
Clausena chemistry MeSH
Culex drug effects MeSH
Insecticides analysis MeSH
Mosquito Vectors MeSH
Larva drug effects MeSH
Plant Leaves chemistry MeSH
Cyclohexane Monoterpenes MeSH
Monoterpenes chemistry MeSH
Houseflies drug effects MeSH
Oils, Volatile chemistry MeSH
Peroxides chemistry MeSH
Gas Chromatography-Mass Spectrometry MeSH
Animals MeSH
Check Tag
Animals MeSH
Publication type
Journal Article MeSH
Geographicals
Cameroon MeSH
Names of Substances
ascaridole MeSH Browser
Insecticides MeSH
Cyclohexane Monoterpenes MeSH
Monoterpenes MeSH
Oils, Volatile MeSH
Peroxides MeSH

Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae) and Clausena anisata (Willd.) Hook. f. ex Benth. (Rutaceae) are two aromatic species traditionally used in Cameroon to repel and kill insects. The present work was carried out to substantiate this traditional use and to evaluate the possible incorporation in commercial botanical insecticides of their essential oils (EOs). The EOs were distilled from leaves of C. anisata and aerial parts of D. ambrosioides and analyzed by gas chromatography-mass spectrometry (GC-MS). The insecticidal activity of both EOs was investigated against the filariasis vector, Culex quinquefasciatus, and the housefly, Musca domestica. As possible mode of action, the inhibition of acetylcholinesterase (AChE) by the two EOs was investigated as well. The D. ambrosioides EO was characterized by the monoterpene peroxide ascaridole (61.4%) and the aromatic p-cymene (29.0%), whereas the C. anisata EO was dominated by the phenylpropanoids (E)-anethole (64.6%) and (E)-methyl isoeugenol (16.1%). The C. anisata EO proved to be very toxic to third instar larvae of C. quinquefasciatus showing LC50 of 29.3 μl/l, whereas D. ambrosioides EO was more toxic to adults of M. domestica showing a LD50 of 51.7 μg/adult. The mixture of both EOs showed a significant synergistic effect against mosquito larvae with LC50 estimated as 19.3 μl/l, whereas this phenomenon was not observed upon application to M. domestica adults (LD50 = 75.9 μg/adult). Of the two EOs, the D. ambrosioides one provided a good inhibition of AChE (IC50 = 77 μg/ml), whereas C. anisata oil was not effective. These findings provide new evidences supporting the ethno-botanical use of these two Cameroonian plants, and their possible application even in synergistic binary blends, to develop new eco-friendly, safe and effective herbal insecticides.

Crop Research Institute Drnovska 507 161 06 Prague 6 Czech Republic

Department of Agriculture Food and Environment University of Pisa via del Borghetto 80 56124 Pisa Italy

Laboratory of Biochemistry of Medicinal Plants Food Science and Nutrition Faculty of Science University of Dschang Dschang Cameroon

Laboratory of Environmental and Applied Chemistry Faculty of Science University of Dschang Dschang Cameroon

School of Pharmacy University of Camerino Camerino Italy

School of Science and Technology University of Camerino Camerino Italy

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