Paramagnetic 19F Relaxation Enhancement in Nickel(II) Complexes of N-Trifluoroethyl Cyclam Derivatives and Cell Labeling for 19F MRI
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
- MeSH
- komplexní sloučeniny chemická syntéza chemie farmakologie toxicita MeSH
- ligandy MeSH
- magnetická rezonanční tomografie metody MeSH
- makrocyklické laktamy chemická syntéza chemie farmakologie toxicita MeSH
- mezenchymální kmenové buňky metabolismus MeSH
- molekulární struktura MeSH
- nikl chemie MeSH
- potkani inbrední LEW MeSH
- radiofarmaka chemická syntéza chemie farmakologie toxicita MeSH
- radioizotopy fluoru MeSH
- stabilita léku MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- komplexní sloučeniny MeSH
- ligandy MeSH
- makrocyklické laktamy MeSH
- nikl MeSH
- radiofarmaka MeSH
- radioizotopy fluoru MeSH
1,8-Bis(2,2,2-trifluoroethyl)cyclam (te2f) derivatives with two coordinating pendant arms involving methylenecarboxylic acid (H2te2f2a), methylenephosphonic acid (H4te2f2p), (2-pyridyl)methyl (te2f2py), and 2-aminoethyl arms (te2f2ae) in 4,11-positions were prepared, and their nickel(II) complexes were investigated as possible 19F MR tracers. The solid-state structures of several synthetic intermediates, ligands, and all complexes were confirmed by X-ray diffraction analysis. The average Ni···F distances were determined to be about 5.2 Å. All complexes exhibit a trans-III cyclam conformation with pendant arms bound in the apical positions. Kinetic inertness of the complexes is increased in the ligand order te2f2ae ≪ te2f < te2f2py ≈ H4te2f2p ≪ H2te2f2a. The [Ni(te2f2a)] complex is the most kinetically inert Ni(II) complex reported so far. Paramagnetic divalent nickel caused a shortening of 19F NMR relaxation time down to the millisecond range. Solubility, stability, and cell toxicity were only satisfactory for the [Ni(te2f2p)]2- complex. This complex was visualized by 19F MRI utilizing an ultrashort echo time (UTE) imaging pulse sequence, which led to an increase in sensitivity gain. Mesenchymal stem cells were successfully loaded with the complex (up to 0.925/5.55 pg Ni/F per cell).19F MRI using a UTE pulse sequence provided images with a good signal-to-noise ratio within the measurement time, as short as tens of minutes. The data thus proved a major sensitivity gain in 19F MRI achieved by utilization of the paramagnetic (transition) metal complex as 19F MR tracers coupled with the optimal fast imaging protocol.
Citace poskytuje Crossref.org
Low-molecular-weight paramagnetic 19F contrast agents for fluorine magnetic resonance imaging
Fluorine polymer probes for magnetic resonance imaging: quo vadis?
